Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure  

作　　者：Yong Lin Geng-Jie Yan Mei-Yan Liu Yin Cao Kan Zhang Na Wang Fu-Li Long De-Wen Mao 

机构地区：[1]Graduate School,Guangxi University of Chinese Medicine,Nanning 530200,Guangxi Zhuang Autonomous Region,China [2]Guangxi School of Chinese Medicine,Guangxi University of Traditional Chinese Medicine,Nanning 530022,Guangxi Zhuang Autonomous Region,China [3]Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi Zhuang Autonomous Region,China [4]Department of Administration,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2024年第27期6045-6056,共12页世界临床病例杂志

基　　金：The National Natural Science Foundation of China,No.82260907,No.82260899,and No.82274434.

摘　　要：Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor affecting LF prognosis.Interleukins(Ils)are a type of cytokine that act and interact with multiple cells,including immune cells.These signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory response.To date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of LF.This article reviews the potential use of Ils as the prognostic biomarkers of LF.Particularly,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to LF.Harnessing biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient survival.Thus,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.

关 键 词：INTERLEUKIN-21 INTERLEUKIN-22 Interleukin-31 Liver failure Biological markers Potential value 

分 类 号：R575.3[医药卫生—消化系统]