INTERLEUKIN-22

作品数：28被引量：225H指数：9
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相关领域：医药卫生更多>>
相关作者：李兰黄宇宁琴黄加权王洪武更多>>
相关机构：华中科技大学郑州大学第五附属医院苏州大学健能隆医药技术(上海)有限公司更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《广西医科大学学报》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金广东省自然科学基金湖北省自然科学基金长江学者和创新团队发展计划更多>>
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Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure被引量：1
《World Journal of Clinical Cases》2024年第27期6045-6056,共12页Yong Lin Geng-Jie Yan Mei-Yan Liu Yin Cao Kan Zhang Na Wang Fu-Li Long De-Wen Mao 
The National Natural Science Foundation of China,No.82260907,No.82260899,and No.82274434.
Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor aff...
关键词：INTERLEUKIN-21 INTERLEUKIN-22 Interleukin-31 Liver failure Biological markers Potential value 
Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22
《World Journal of Gastrointestinal Surgery》2023年第12期2866-2878,共13页Heng Zhou Ju-Ling Xu San-Xiong Huang Ying He Xiao-Wei He Sheng Lu Bin Yao 
Supported by the Natural Science Foundation of Zhejiang Province,No.LQ20H310002;the Scientific Technology Projects of Health and Medicine of Zhejiang Province,No.2020KY308;and the Huzhou Science and Technology Fund,No.2020GY39.
BACKGROUND Rapid regeneration of the residual liver is one of the key determinants of successful partial hepatectomy(PHx).At present,there is a lack of recognized safe,effective,and stable drugs to promote liver regen...
关键词：INTERLEUKIN-22 Partial hepatectomy Hepatic vagotomy Liver regeneration Signal transducer and activator of transcription 3 Interleukin-22 binding protein 
Mechanism of iron on the intestinal epithelium development in suckling piglets被引量：3
《Science China(Life Sciences)》2023年第9期2070-2085,共16页Lanmei Yin Yitong Zhang Jun Li Jing Zhou Qiye Wang Jing Huang Jianzhong Li Huansheng Yang 
supported by the National Natural Science Foundation of China (32130099);the Science and Technology Innovation Program of Hunan Province (2022RC3060);the Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process open fund projects (ISA2020113)。
This study aimed to investigate the mechanism of iron on intestinal epithelium development of suckling piglets. Compared with newborn piglets, 7-day-old and 21-day-old piglets showed changes in the morphology of the j...
关键词：IRON suckling piglets intestinal epithelium development INTERLEUKIN-22 
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s被引量：38
《Acta Pharmacologica Sinica》2022年第6期1495-1507,共13页Yan-yang Li Xiao-jing Wang Yu-lin Su Qing Wang Shao-wei Huang Zeng-feng Pan Yan-ping Chen Jun-jie Liang Mei-ling Zhang Xue-qian Xie Zhi-yun Wu Jin-yan Chen Lian Zhou Xia Luo 
This work was supported by the National Natural Science Foundation of China(Grant No.82074092);Characteristic Innovation Project of Guangdong Provincial Universities(Grant No.2020KTSCX026);“Double First-class”and High-level University Discipline Collaborative Innovation Team Project of Guangzhou University of Chinese Medicine(Grant No.2021xk81);Natural Science Foundation of Guangdong Province(Grant no.2021A1515012219);Guangdong Provincial Bureau of Traditional Chinese Medicine(Grant no.20181076).
Ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is closely related to gut barrier dysfunction.Emerging evidence shows that interleukin-22(IL-22)derived from group 3 innate l...
关键词：ulcerative colitis BAICALEIN epithelial barrier group 3 innate lymphoid cells INTERLEUKIN-22 aryl hydrocarbon receptor CH223191 FICZ 
VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses被引量：10
《Acta Pharmaceutica Sinica B》2021年第1期127-142,共16页Yilan Shen Wei Chen Lei Han Qi Bian Jiajun Fan Zhonglian Cao Xin Jin Tao Ding Zongshu Xian Zhiyong Guo Wei Zhang Dianwen Ju Xiaobin Mei 
supported by grants from the National Natural Science Foundation of China(31872746 and 81773620);Scientific Research Projects of Shanghai Municipal Commission of Health and Family Planning(201740140,China)
Diabetic nephropathy(DN)is considered the primary causes of end-stage renal disease(ESRD)and is related to abnormal glycolipid metabolism,hemodynamic abnormalities,oxidative stress and chronic inflammation.Antagonism ...
关键词：Diabetic nephropathy Vascular endothelial growth factor B INTERLEUKIN-22 Fusion protein 
Role of regenerating islet-derived proteins in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2020年第21期2702-2714,共13页Jodi-Ann Edwards Nicholas Tan Nadlie Toussaint Peiqi Ou Cathy Mueller Albert Stanek Vladimir Zinsou Sean Roudnitsky Michelle Sagal Lisa Dresner Alexander Schwartzman Chongmin Huan 
Inflammatory bowel disease(IBD)is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide.It has a complex and multifactorial etiology leading to excessive exposure of intest...
关键词：Regenerating islet-derived proteins Inflammatory bowel disease Crohn’s disease Ulcerative colitis INTERLEUKIN-22 Intestinal bacteria 
Interleukin-22 from bench to bedside:a promising drug for epithelial repair被引量：7
《Cellular & Molecular Immunology》2019年第7期666-667,共2页Bin Gao Xiaogang Xiang 
the intramural program of the NIAAA and NIH(B.G.).
Cellular and Molecular Immunology(CMI),the official journal of theChinese Society of Immunology,was established in 2004.CMI hasnow become one of the leading international journals in the fieldand publishes high-qualit...
关键词：IMMUNOLOGY protective INTERLEUKIN 
Interaction of IL-22/IL-22R1 promotes cell proliferation and suppresses apoptosis of colorectal cancer via phosphorylation of STAT3
《BIOCELL》2019年第2期89-98,共10页XIAONING QIN LIQING YUAN HONGXUN RUAN LIN LIN 
Interleukin-22(IL-22)is a member of IL-10 cytokine family which is expressed in activated T cells predominantly and in activated natural killer cells at lower levels.Previous studies have demonstrated the link between...
关键词：INTERLEUKIN-22 Colorectal cancer PI3K/Akt signaling pathway STAT3 
Interleukin-22 receptor 1 is expressed in multinucleated giant cells:A study on intestinal tuberculosis and Crohn’s disease被引量：5
《World Journal of Gastroenterology》2019年第20期2473-2488,共16页Zi-Qi Yu Wen-Fei Wang You-Chao Dai Xin-Chun Chen Jian-Yong Chen 
Supported by Key R&D Plan of Science and Technology Department of Jiangxi Province,No.20171BBG70087
BACKGROUND It is challenging to distinguish intestinal tuberculosis from Crohn’s disease due to dynamic changes in epidemiology and similar clinical characteristics. Recent studies have shown that polymorphisms in ge...
关键词：Crohn's disease INTESTINAL tuberculosis Single-nucleotide polymorphism INTERLEUKIN-22 INTERLEUKIN-22 RECEPTOR 1 Multinucleated giant cells 
Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects被引量：7
《Cellular & Molecular Immunology》2019年第5期473-482,共10页Kai-Yang Tang Jason Lickliter Zhi-Hua Huang Zong-Shu Xian Han-Yang Chen Cheng Huang Chong Xiao Yu-Peng Wang Ying Tan Lin-Feng Xu Yu-Liang Huang Xiao-Qiang Yan 
F-652 is a recombinant fusion protein consisting of two human interleukin-22(IL-22)molecules linked to an immunoglobulin constant region(IgG 2-Fc).IL-22 plays critical roles in promoting tissue repair and suppressing ...
关键词：INTERLEUKIN-22 F-652 PHARMACOKINETICS PHARMACODYNAMICS SAFETY 
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