T-CELL

作品数：321被引量：729H指数：12
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相关机构：北京协和医院广西医科大学郑州大学第一附属医院华中科技大学更多>>
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Fourth-generation chimeric antigen receptor T-cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis
《Cell Research》2025年第3期220-223,共4页Yujing Li Sujun Li Xiaojuan Zhao Jun Sheng Lei Xue Georg Schett Ce Shi Biliang Hu Xingbing Wang Zhu Chen 
supported by the National Natural Science Foundation of China(82471819 and 81871227 to Z.C.);Anhui Provincial Health Research Foundation(AHWJ2023A10120 to Z.C.);Anhui Provincial Natural Science Foundation(2408085J046 to Z.C.);Anhui Provincial Key Research and Development Plan(2022h11020009 to Z.C.);the Fundamental Research Funds for the Central Universities(YD9110002012 to Z.C.).
Dear Editor,Rheumatoid arthritis(RA)is an autoimmune inflammatory disease characterized by symmetric synovial inflammation leading to progressive disability.1 Treatment of RA has been revolutionized by the development...
关键词：chimeric antigen receptor autoimmune inflammatory disease fourth generation t cell therapy treatment resistant tolerable rheumatoid arthritis symmetric synovial inflammation 
Acellular scaffold‑based approach for in situ genetic engineering of host T‑cells in solid tumor immunotherapy
《Military Medical Research》2025年第1期16-35,共20页Hiren Y.Dandia Mamatha M.Pillai Deepak Sharma Meghna Suvarna Neha Dalal Ayush Madhok Arvind Ingle Shubhada V.Chiplunkar Sanjeev Galande Prakriti Tayalia 
Department of Biotechnology(DBT,Govt of India)(BT/PR31315/MED/32/667/2019);DBT along with Wadhwani Research Center for Bioengineering,IIT Bombay(BT/INF/22/SP23026/2017);Department of Biotechnology(DBT,Govt of India)(BT/INF/22/SP17358/2016).
Background:Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies.However,its application to solid tumors presents significant challenges due to the limited accessi...
关键词：Polyethylene glycol diacrylate POLY-L-LYSINE LENTIVIRUSES T-cell therapy B16F10-OVA melanoma 
Tumor-intrinsic PRMT5 upregulates FGL1 via methylating TCF12 to inhibit CD8^(+) T-cellmediated antitumor immunity in liver cancer
《Acta Pharmaceutica Sinica B》2025年第1期188-204,共17页Jiao Sun Hongfeng Yuan Linlin Sun Lina Zhao Yufei Wang Chunyu Hou Huihui Zhang Pan Lv Guang Yang Ningning Zhang Wei Lu Xiaodong Zhang 
supported by the National Natural Science Foundation of China(Nos.82372818 to Xiaodong Zhang,82103066 to Guang Yang,82302887 to Hongfeng Yuan,82303210 to Yufei Wang);The China Postdoctoral Science Foundation(No.2022M712389 to Hongfeng Yuan,No.2023M732624 to Yufei Wang,No.2023M742621 to Lina Zhao);Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-009A to W.Lu,China);“14th Five-Year Plan”Tumor Prevention and Treatment Research Project of Tianjin Medical University Cancer Institute and Hospital(No.YZ-03,China).
Protein arginine methyltransferase 5(PRMT5)acts as an oncogene in liver cancer,yet its roles and in-depth molecular mechanisms within the liver cancer immune microenvironment remain mostly undefined.Here,we demonstrat...
关键词：PRMT5 TCF12 FGL1 Antitumorimmunity Liver cancer 
Free fatty acid receptor-4 regulates T-cellmediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway
《Acta Pharmaceutica Sinica B》2025年第1期224-238,共15页Maxwell Duah Fei Zheng Jingyi Shen Yan Xu Shuo Cao Zhiling Yan Qiu Lan Ying Wang Kailin Xu Bin Pan 
supported by National Natural Science Foundation of China(82170214,81970159 and 82370218 to Bin Pan,81930005 and 82341203 to Kailin Xu);the Jiangsu Provincial Key Research and Development Program(BE2021631 to Bin Pan,China);the Natural Science Research of Jiangsu Higher Education Institutions of China(20KJA320002 to Bin Pan);Prof.Robert Peter Gale(Imperial College of Science,Technology and Medicine)kindly revised the typescript.
Targeting T-cell is a strategy to control allogeneic response disorders,such as acute graftversus-host disease(GVHD)which is an important cause of therapy-failure after allogeneic hematopoietic cell transplants.Free f...
关键词：Free fatty acid receptor-4 CpdA T-CELL Graft-versus-host disease Allogeneic reaction Aryl hydrocarbon receptor INTERLEUKIN-22 OBESITY 
An assessment model for efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk
《Chinese Medical Journal》2025年第1期108-110,共3页Bin Xue Yifan Liu Min Zhang Gangfeng Xiao Xiu Luo Lili Zhou Shiguang Ye Yan Lu Wenbin Qian Li Wang Ping Li Aibin Liang 
supported by grants from the National Key R&D Program of China(No.2021YFA1100800);National Natural Science Foundation of China(Nos.81830004 and 82070168);Translational Research Grant of NCRCH(No.2020ZKZC04);Shanghai Municipal Health Commission(No.2020CXJQ02);Cultivation project of National Natural Science Foundation of Shanghai Tongji Hospital(No.GJPY2332).
To the Editor:Autologous CD19 chimeric antigen receptor(CAR)T-cell therapy has emerged as a crucial treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma(r/r DLBCL).[1]While CAR-T-cel...
关键词：therapeutic efficacy chimeric antigen REFRACTORY predictive model Chimeric Antigen Receptor T cell therapy diffuse large B cell lymphoma 
继发嗜血细胞综合征的NK/T细胞淋巴瘤1例
《中国耳鼻咽喉头颈外科》2024年第12期811-812,共2页王永坤 曲慧 李杭津 王吉喆 张伟 
1临床资料患者,女,46岁,因“口吐鲜血1 d”就诊于大连医科大学附属第二医院。1 d前患者无明显诱因突发口吐鲜血,量约500 ml,完善相关检查提示鼻咽部病变,急诊收入我院介入科。既往体健,1个月前患者无明显诱因出现发热、咽痛,经积极抗炎...
关键词：出血(Hemorrhage) 淋巴瘤 结外NK-T细胞(Lymphoma Extranodal NK-T-Cell) 嗜血细胞综合征(hemophagocytic syndrome) 
Dual role of BCL11B in T-cell malignancies
《Blood Science》2024年第4期36-39,共4页Grzegorz K.Przybylski Julia Przybylska Yangqiu Li 
supported in part by the National Centre for Research and Development,Poland(No.WPC/BCL/2019);the Intergovernmental International Cooperation on Scientific and Technological Innovation Project of Chinese Ministry of Science and Technology(No.2017YFE0131600).
The zinc finger transcription factor B-cell CLL/lymphoma 11B gene(BCL11B,CTIP2)plays a crucial role in T-cell development,but its role in T-cell malignancies has not yet been definitively clarified.In the literature,2...
关键词：BCL11B BER CTIP2 Rit1 T-cell malignancy T-ALL TCL 
No more LAGging behind PD-1:uncovering the unique role of LAG-3 in T-cell exhaustion
《Cellular & Molecular Immunology》2024年第12期1351-1353,共3页Yunju Jo Hyung-seung Jin Yoon Park 
supported by an intramural grant from KIST to YP,as well as grants from the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(NRF-2020M3A9G7103935 and RS-2024-00338729 to HJ and RS-2024-00337093 to YP).
Exhausted T(Tex)cells are a distinct subset of T cells that arise in response to prolonged antigen exposure during chronic infections or cancer.Although Tex cells exhibit reduced functionality,they still retain some p...
关键词：IMMUNITY protective thereby 
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
《Cellular & Molecular Immunology》2024年第12期1426-1440,共15页Xin Liu Mengjie Yang Ping Xu Mingwei Du Shanshan Li Jin Shi Qiang Li Jinfeng Yuan Yu Pang 
supported by the National Key Research and Development Program of China(2022YFC2302901);the National Natural Science Foundation of China(82272346,82072243,82202530);the Sponsored by Beijing Nova Program(20220484169,20230484295);the Provincial Key Research and Development Program of Jiangsu in Social Development(BE2023718).
Tuberculosis,caused by Mycobacterium tuberculosis(Mtb),is a critical global health issue that is complicated by the ability of the pathogen to delay the host’s T-cell immune response.This delay in T-cell recruitment ...
关键词：Mycobacterium tuberculosis Tryptophan metabolism IDO1 IMMUNOSUPPRESSION CHEMOKINES 
Moxibustion inhibits the macrophage M1 polarization toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B signaling pathway by regulating T-cell immunoglobulin and mucin-containing protein-3 in rheumatoid arthritis
《Journal of Traditional Chinese Medicine》2024年第6期1227-1235,共9页LUO Kun ZHONG Yumei GUO Yanding ZHANG Linlin HU Danhui MA Wenbin YANG Xin ZHOU Haiyan 
the National Natural Science Foundation of China:Study on Immunoregulatory Mechanism of Moxibustion"Regulating Weiqi"to Regulate the Intrasynovial Environment Steady State in Rheumatoid Arthritis Model Rats based on the Skin-resident Memory T cells-Growth Arrest-specific 6/Mer Tyrosine Kinase (No. 82374587);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No. 81973959);the National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints (No. 2019YFC1709001);Science and Technology Innovation Seedling Project of Sichuan Province:based on Macrophage M1 Polarization Signaling Pathway Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa B and its Regulatory Molecule T-cell Immunoglobulin and Mucin-containing Protein-3 Exploring the Effect Mechanism of Moxibustion on Experimental Rheumatoid Arthritis Model (No. 2022037)。
OBJECTIVE: To explore whether moxibustion exerts therapeutic effects on rheumatoid arthritis(RA) by regulating the expression of T-cell immunoglobulin and mucin-containing protein-3(TIM-3) and subsequently modulating ...
关键词：MOXIBUSTION ARTHRITIS RHEUMATOID TIM-3 macrophage polarization toll-like receptor 4 myeloid differentiation factor 88 nuclear factor kappa B signal transduction 
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