Role of regenerating islet-derived proteins in inflammatory bowel disease  

作　　者：Jodi-Ann Edwards Nicholas Tan Nadlie Toussaint Peiqi Ou Cathy Mueller Albert Stanek Vladimir Zinsou Sean Roudnitsky Michelle Sagal Lisa Dresner Alexander Schwartzman Chongmin Huan 

机构地区：[1]Department of Surgery,State University of New York,Downstate Health Sciences University,Brooklyn,NY 11203,United States [2]College of Medicine,State University of New York,Downstate Health Sciences University,Brooklyn,NY 11203,United States [3]MCB program,School of Graduate Studies,State University of New York,Downstate Health Sciences University,Brooklyn,NY 11203,United States [4]Department of Surgery and Cell Biology,State University of New York,Downstate Health Sciences University,Brooklyn,NY 11203,United States

出　　处：《World Journal of Gastroenterology》2020年第21期2702-2714,共13页世界胃肠病学杂志（英文版）

摘　　要：Inflammatory bowel disease(IBD)is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide.It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to microbial antigens,inappropriate activation of the immune system and ultimately to the damage of intestinal tissues.Although numerous efforts have been made to improve the disease management,IBD remains persistently recurring and beyond cure.This is due largely to the gaps in our understanding of the pathogenesis of IBD that hamper the development of timely diagnoses and effective treatment.However,some recent discoveries,including the beneficial effects of interleukin-22(IL-22)on the inflamed intestine,have shed light on a self-protective mechanism in IBD.Regenerating islet-derived(REG/Reg)proteins are small secretory proteins which function as IL-22’s downstream effectors.Mounting studies have demonstrated that IBD patients have significantly increased REG expressions in the injured intestine,but with undefined mechanisms and roles.The reported functions of REG/Reg proteins in intestinal homeostasis,such as those of antibacterial,anti-inflammatory and tissue repair,lead us to discuss their potential mechanisms and clinical relevance in IBD in order to advance IBD research and management.

关 键 词：Regenerating islet-derived proteins Inflammatory bowel disease Crohn’s disease Ulcerative colitis INTERLEUKIN-22 Intestinal bacteria 

分 类 号：R574[医药卫生—消化系统]