Follicular helper T lymphocytes in health and disease  

作　　者：Cecilia Parodi María Noel Badano Nora Galassi Ana Coraglia Patricia Baré Alejandro Malbrán María Marta de Elizalde de Bracco 

机构地区：[1]Department of Immunology,Instituto de Medicina Experimental (IMEX)– CONICET-Academia Nacional de Medicina (ANM) Pacheco de Melo 3081,Ciudad Autónoma de Buenos Aires 1425,Argentina [2]Department of Virology,Instituto de Investigaciones Hematológicas Mariano Castex (IIHEMA)-ANM,Pacheco de Melo 3081,Ciudad Autónoma de Buenos Aires 1425,Argentina [3]Unidad de Alergia e Inmunología Clínica,Av. Pte. Roque Saenz Pe?a 1160,Ciudad Autónoma de Buenos Aires C1431GHA,Buenos Aires,Argentina

出　　处：《World Journal of Hematology》2014年第4期118-127,共10页世界血液学杂志

基　　金：Supported by Consejo Nacional de Investigaciones Científicas y Técnicas,CONICET,PIP Nos.0032 and 11220120100619CO

摘　　要：A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes(T FH) in this reaction. We shall focus on the regulation of their development and function in health and disease. T FH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper Ig M syndrome orX-linked lymphoproliferative disease. Increased numbers of T FH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating T FH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of T FH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes(T FH) in this reaction. We shall focus on the regulation of their development and function in health and disease. T FH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper Ig M syndrome orX-linked lymphoproliferative disease. Increased numbers of T FH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating T FH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of T FH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.

关 键 词：FOLLICULAR helper T(TFH)lymphocytes TFH development Chemokine(C-X-C motif)receptor 5 INTERLEUKIN-21 Programmed CELL death-1/Programmed CELL death ligand 1(PDL-1)or PDL-2 Primary IMMUNODEFICIENCIES Autoimmunity Chronic viral INFECTIONS Protozoan INFECTIONS 

分 类 号：R[医药卫生]