Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study  

作　　者：Wan-Hua Xu Li-Chan Mo Mao-Hua Shi Hui Rao Xiao-Yong Zhan Mo Yang 

机构地区：[1]Department of Hematology,Nanfang Hospital/The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of Emergency Medicine,The First People’s Hospital of Foshan,Foshan 528000,Guangdong Province,China [3]Department of Emergency Medicine,Nanfang Hospital/The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,Guangdong Province,China [4]Department of Rheumatology and Immunology,The First People’s Hospital of Foshan,Foshan 528000,Guangdong Province,China [5]Scientific Research Center,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107,Guangdong Province,China [6]Department of Pediatrics,Nanfang Hospital/The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2022年第13期4072-4083,共12页世界临床病例杂志

基　　金：Supported by the Guangdong Province Medical Science and Technology Research Foundation,No.B2014377;the Medical Scientific Research Project of Foshan,No.20190036.

摘　　要：BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological conditions.TPO,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation and differentiation of megakaryocytes.However,the role of TPO in sepsis is not well determined.The elevated levels of TPO are often accompanied by a decrease of platelet count(PLT)in systemic infected conditions,which is contrary to the view that TPO promotes platelet production under physiological conditions.In addition,whether TPO mediates organ damage in sepsis remains controversial.AIM To explore the relationships between TPO and inflammatory factors,platelet indices,and thrombotic indicators in sepsis.METHODS A total of 90 patients with sepsis diagnosed and treated at the emergency medicine department of The First People’s Hospital of Foshan between January 2020 and March 2021 were enrolled in this study.In addition,110 patients without sepsis who came to the emergency medicine department were included as controls.Clinical and laboratory parameters including age,gender,TPO,blood cell count in peripheral blood,platelet indices,inflammatory factors such as high-sensitivity Creactive protein(hs-CRP),interleukin(IL)-21,and IL-6,organ damage indicators,and thrombotic indicators were collected and analyzed by using various statistical approaches.RESULTS The results showed that the TPO levels were higher in the sepsis group than in controls[86.45(30.55,193.1)vs 12.45(0.64,46.09)pg/mL,P<0.001],but PLT was lower(P<0.001).Multivariable analysis showed that white blood cell count(WBC)[odds ratio(OR)=1.32;95%confidence interval(CI):1.01-1.722;P=0.044],TPO(OR=1.02;95%CI:1.01-1.04;P=0.009),IL-21(OR=1.02;95%CI:1.00-1.03;P=0.019),troponin I(OR=55.20;95%CI:5.69-535.90;P=0.001),and prothrombin time(PT)(OR=2.24;95%CI:1.10-4.55;P=0.027)were independent risk factors associated with sepsis.TPO levels were positively correlated with IL-21,IL-6,hs-CRP,creatinine,D-dimer,PT,activated prothrombin time,international nor

关 键 词：SEPSIS THROMBOPOIETIN INTERLEUKIN-21 PLATELETS THROMBOSIS 

分 类 号：R459.7[医药卫生—急诊医学]