High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer  

作　　者：Zoltan Herold Magdolna Herold Gyorgy Herczeg Agnes Fodor Attila Marcell Szasz Magdolna Dank Aniko Somogyi 

机构地区：[1]Division of Oncology,Department of Internal Medicine and Oncology,Semmelweis University,Budapest H-1083,Hungary [2]Department of Internal Medicine and Hematology,Semmelweis University,Budapest H-1088,Hungar [3]Department of General Surgery,Szent Imre University Teaching Hospital,Budapest H-1115,Hungary

出　　处：《World Journal of Clinical Cases》2022年第13期4084-4096,共13页世界临床病例杂志

基　　金：Supported by the National Research,Development and Innovation Office,No.K-116128;the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund,No.UNKP-20-4-I.

摘　　要：BACKGROUND Colorectal cancer(CRC)is often associated with elevated platelet count(>400×10^(9)/L),known as thrombocytosis.The role of CD40 ligand(CD40L),a member of the tumor necrosis factor family,is controversial in CRC.Circulating CD40L is higher in CRC,but its relationship with disease staging and local and distant metastasis is not clear.Although most of the circulating CD40L is produced by platelets,no previous study investigated its relationship with CRC-related thrombocytosis.AIM To investigate the role of CD40L to predict the outcome of CRC and its relation to thrombocytosis.METHODS A total of 106 CRC patients and 50 age and sex-matched control subjects were enrolled for the study.Anamnestic data including comorbidities and histopathological data were collected.Laboratory measurements were performed at the time of CRC diagnosis and 1.5 mo and at least 6 mo after the surgical removal of the tumor.Plasma CD40L and thrombopoietin were measured via enzyme-linked immunosorbent assay,while plasma interleukin-6 was measured via electrochemiluminescence immunoassay.Patient follow-ups were terminated on January 31,2021.RESULTS Plasma CD40L of CRC patients was tendentiously higher,while platelet count(P=0.0479),interleukin-6(P=0.0002),and thrombopoietin(P=0.0024)levels were significantly higher as opposed to the control subjects.Twelve of the 106 CRC patients(11.3%)had thrombocytosis.Significantly higher CD40L was found in the presence of distant metastases(P=0.0055)and/or thrombocytosis(P=0.0294).A connection was found between CD40L and platelet count(P=0.0045),interleukin-6(P=0.0130),and thrombocytosis(P=0.0155).CD40L was constant with the course of CRC,and all baseline differences persisted throughout the whole study.Both pre-and postoperative elevated platelet count,CD40L,and interleukin-6 level were associated with poor overall and disease-specific survival of patients.The negative effect of CD40L and interleukin-6 on patient survival remained even after the stratification by thrombocytosis.CONCLUSION CD40L l

关 键 词：CD40 ligand Colorectal neoplasms INTERLEUKIN-6 THROMBOCYTOSIS THROMBOPOIETIN 

分 类 号：R735.34[医药卫生—肿瘤]