ELTROMBOPAG

作品数：27被引量：54H指数：3
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相关领域：医药卫生更多>>
相关作者：沈志祥姚善谦卢学春朱宏丽陈常青更多>>
相关机构：上海交通大学中国人民解放军总医院天津药物研究院武汉大学更多>>
相关期刊：《国外药讯》《世界临床药物》《中国药物化学杂志》《Cancer Pathogenesis and Therapy》更多>>
相关基金：国家自然科学基金中国博士后科学基金北京市自然科学基金更多>>
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Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia:real-world data from a single medical center
《China Medical Abstracts(Internal Medicine)》2024年第3期183-184,共2页DONG Xifeng 
Objective To investigate the efficacy and safety of eltrombopag in the treatment of adult primary immune thrombocytopenia (ITP) and evaluated the factors influencing its efficacy and side effects.Methods A total of 19...
关键词：admitted TREATMENT IMMUNE 
Spotlight on eltrombopag concentration in pediatric immune thrombocytopenia:A single-center observational study in China
《Pediatric Investigation》2024年第1期44-52,共9页Shuyue Dong Zhifa Wang Nan Wang Jingyao Ma Jinxi Meng Yixin Sun Xiaoling Cheng Runhui Wu 
Capital’s Funds for Health Improvement and Research:Grant/Award Number:2022-2Z-2099 Beijing Municipal Administration of Hospitals Incubating Program:Grant/Award Number:PX2023044;National Natural Science Foundation of China:Grant/Award Number:81970111;Funding for Reform and development of Beijing Municipal Health Commission National Key R&D Program of China:Grant/Award Number:2023YFC2706100。
Importance:Eltrombopag has been recommended for pediatric immune thrombocytopenia(ITP).Response and adverse drug reactions(ADRs)varied widely between individuals,even at the same dose of eltrombopag.The appropriate el...
关键词：CONCENTRATION Efficacy ELTROMBOPAG Immune thrombocytopenia Pedi-atrics Safety 
Combination of two target agonists of the thrombopoietin and thrombopoietin receptor in the treatment of elderly patients with refractory immune thrombocytopenia
《Cancer Pathogenesis and Therapy》2023年第2期154-156,共3页Jundong Zhang Zining Wang Haoran Chen Xuechun Lu 
supported by the National Key Research and Development Program of China(No.2020YFC2002706);the Army Health Care Special Project(No.19BJZ28).
Immune thrombocytopenia(ITP)is common in the elderly.Because of the coexistence of multiple diseases,there are many reservations regarding corticosteroid use in the elderly.Thrombopoietin(TPO)and its analogs can promo...
关键词：Immune thrombocytopenia(ITP) TPO-MPL signaling Pathway rh-TPO ELTROMBOPAG 
Adding cyclosporin A to eltrombopag for aplastic anemia secondary to chemotherapy for solid cancers被引量：2
《Chinese Medical Journal》2023年第9期1120-1122,共3页Ziqi Wan Yang Chen Junling Zhuang Miao Chen Shuyang Zhang Bing Han 
Chinese Acadmy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS 2021-1-I2M-003);PUMCH National High-Level Hospital Clinical Research Funding(Nos.2022-PUMCH-C-026,2022-PUMCH-D-002,2022-PUMCH-B-046)
To the Editor:Myelosuppression is one of the most common side effects of chemotherapy.Some patients would develop long-lasting aplastic anemia(AA)even after stopping chemotherapy for over three months,due to persisten...
关键词：ANEMIA CHEMOTHERAPY CYCLOSPORIN 
Switching between eltrombopag and recombinant human thrombopoietin in patients with immune thrombocytopenia: an observational study被引量：1
《Chinese Medical Journal》2022年第19期2344-2350,共7页Xuan Cai Xiaixia Fu Xiangyu Zhao Jin Lu Qian Jiang Yingjun Chang Xiaojun Huang Xiaohui Zhang 
Beijing Natural Science Foundation(No.H2018206423);National Natural Science Foundation of China(No.81970113);Key Program of National Natural Science Foundation of China(No.81730004);National Key Research and Development Program of China(No.2017YFA0105503)。
Background:Recombinant human thrombopoietin(rh-TPO)and eltrombopag are two distinct TPO receptor agonists(TPO-RAs)with different mechanisms.During the pandemic,when immunosuppressive medications are controversial,swit...
关键词：Immune thrombocytopenia Treatment switching Treatment outcome ELTROMBOPAG THROMBOPOIETIN 
Epstein–Barr-virus-associated hepatitis with aplastic anemia: A case report
《World Journal of Clinical Cases》2022年第23期8242-8248,共7页Wan-Jun Zhang Li-Qiang Wu Jun Wang Sheng-Yun Lin Bo Wang 
BACKGROUND Hepatitis-associated aplastic anemia(HAAA) is a rare condition. Patients with HAAA usually present with acute hepatitis, jaundice and significantly increased transaminase. After 1–2 mo, hepatitis gradually...
关键词：Epstein-Barr virus Hepatitis-associated aplastic anemia Immunosuppressive therapy ELTROMBOPAG Case report 
Successful treatment in one myelodysplastic syndrome patient with primary thrombocytopenia and secondary deep vein thrombosis:A case report
《World Journal of Clinical Cases》2022年第14期4640-4647,共8页Wen-Bin Liu Jian-Xiong Ma Hong-Xuan Tong 
Supported by the Zhejiang Province Administration of Traditional Chinese Medicine,No.2017ZB034 and No.2020ZB096;the Zhejiang University of Traditional Chinese Medicine School-Level Fund,No.2019ZG06;the National Nonprofit Institute Research Grant for Institute of Basic Theory for Chinese Medicine,CACMS,No.YZ-202142.
BACKGROUND The contradictory process of coagulation and anticoagulation maintains normal physiological function,and platelets(PLTs)play a key role in hemostasis and bleeding.When severe thrombocytopenia and deep vein ...
关键词：THROMBOCYTOPENIA Deep vein thrombosis Fondaparinux sodium THROMBOPHILIA Myelodysplastic syndrome ELTROMBOPAG Case report 
Successful treatment of refractory pure red cell aplasia with eltrombopag after ABO-incompatible allogeneic hematopoietic stem cell transplantation被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第8期695-700,共6页Yang GAO Fei GAO Jimin SHI Huarui FU He HUANG Yanmin ZHAO 
supported by the National Natural Science Foundation of China (No. 81670148);the Health Science and Technology Project of Zhejiang Province (No. 2012KYB079), China。
Pure red cell aplasia(PRCA) is a well-recognized complication of ABO major mismatched allogeneic hematopoietic stem cell transplantation(allo-HSCT), with a reported incidence of 10% – 20%(Zhidong et al., 2012;Busca e...
关键词：ABO al. HEMATOPOIETIC 
Eltrombopag-related renal vein thromboembolism in a patient with immune thrombocytopenia: A case report被引量：4
《World Journal of Clinical Cases》2021年第11期2611-2618,共8页Cen Wu Xiao-Ming Zhou Xiao-Dong Liu 
The Natural Science Funding Guidance Project of Liaoning Province,No.2018011494-301;345 Talent Program of Shengjing Hospital,China Medical University.
BACKGROUND Eltrombopag is an orally administered thrombopoietin receptor agonist linked to a heightened risk of treatment-related thromboembolism.Both venous and arterial thromboses have been documented in the medical...
关键词：ELTROMBOPAG Immune thrombocytopenic purpura Thrombopoietin receptor agonist Renal vein thrombosis Case report 
Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein被引量：3
《Acta Pharmaceutica Sinica B》2020年第8期1414-1425,共12页Yuying Zhu Liuqing Yang Jiazhen Xu Xiyan Yang Pengwei Luan Qianfei Cui Pei Zhang Feiyun Wang Ruixiang Li Xinyue Ding Lixian Jiang Guoqiang Lin Jiange Zhang 
supported by National Natural Science Foundation of China(81573579);the New Interdisciplinary Subject Funding Program for Shanghai Traditional Chinese Medicine(E2-F18003,China);Shanghai Municipal Education Commission(SMEC,2019-01-07-00-10-E00072,China);Science and Technology Commission of Shanghai Municipality(STCSM,18401933500,China);Postdoctoral Science Foundation of China(A2-X1802408);Shanghai Municipal Commission of Health and Family Planning(2018YQ003,China)
HuR(human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescen...
关键词：RAW264.7 ELTROMBOPAG ANGIOGENESIS 
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