Aplastic anemia (AA) is a rare, life-threatening disease characterized by pancytopenia and bone marrow failure. However, since the introduction of immunosuppressive therapy and allogeneic stem cell transplantation, ou...
Chinese Acadmy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS 2021-1-I2M-003);PUMCH National High-Level Hospital Clinical Research Funding(Nos.2022-PUMCH-C-026,2022-PUMCH-D-002,2022-PUMCH-B-046)
To the Editor:Myelosuppression is one of the most common side effects of chemotherapy.Some patients would develop long-lasting aplastic anemia(AA)even after stopping chemotherapy for over three months,due to persisten...
supported in part by JSPS KAKENHI Grant Number JP19K08323(H.S.)from the Ministry of Education,Culture,Sports.
Although the standard treatment for Kawasaki disease(KD)is intravenous immunoglobulin(IVIG)combined with oral aspirin,18%of 1st IVIG is refractory[1].Recently,the efficacy of immunomodulatory drugs for IVIG-resistant ...
BACKGROUND Solid organ transplantation is a life-saving intervention for end-stage organ disease.Post-transplant diabetes mellitus(PTDM)is a common complication in solid organ transplant recipients,and significantly c...
Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in dividuals.Cyclospori n A(CsA),a fungal metabolite,has been reported to...
Supported by the National Natural Science Foundation of China(No.81202991);Tianjin City Application Basis,Cutting-edge Technology Research Program(Tianjin Municipal Science and Technology Commission,No.13JCYBJC38500)
Objective: To test the role of psoralidin in human liver cancer HepG2 cells in vitro. Methods: Cell viability was assessed by methylthiazolyldiphenyl-tetrazolum bromide assay and apoptotic cells were labeled by annexi...
Recently there has been a resurgence of interest in cyclic peptides due to their therapeutic advantages in terms of potency, permeability, proteolytic stability, and unique selectivity relative to traditional smaller ...
Supported by Kiriwina Investments Limited of Australia
AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral cons...
Aim: Co-administration of diltiazem can reduce the dosage of cyclosporine (CsA) in patients with renal transplantation. In this study, we investigated how diltiazem altered the relationship between MDR1 genetic pol...
Objective To evaluate the clinical efficacy and safety of human leukocyte antigen(HLA)haploidentical stem cell transplantation in nonmalignant hematologic diseases.Methods To analyze the outcome of 13 patients with no...