TRANSDERMAL

作品数：83被引量：126H指数：6
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相关领域：医药卫生更多>>
相关作者：王留义郑俊民李守峰王丽霞张永珍更多>>
相关机构：沈阳药科大学河南省人民医院北京大学第三医院北华大学更多>>
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相关基金：国家自然科学基金北京市自然科学基金中国博士后科学基金广东省自然科学基金更多>>
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Macro-to-nano dynamic hydrogels in sustained transdermal therapy of diffuse ocular surface malignancies
《Nano Research》2025年第3期372-385,共14页Jie Chen Yirong Zeng Hao Tian Qixiao Guan Ziyue Huang Hongjing Dou Shiqiong Xu Renbing Jia 
supported by grants from the Science and Technology Commission of Shanghai(No.22Y31900700);Program of Innovative Research Team of High-Level Local Universities in Shanghai(No.SHSMU-ZDCX20210902);Shanghai Municipal Health Commission(No.2022YQ01);“New Star of Medical College”Young Medical Talents Training Program in Shanghai in 2020 and Cross-Disciplinary Research Fund Project of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYJC202303).
Conjunctival melanoma(CοM)is of high malignancy that diffusely impacts the ocular surface,which is challenging to surgically remove and pose a life-threatening risk.As one of the most suitable treatment options,drug ...
关键词：HYDROGELS targeted therapy conjunctival melanoma ocular surface malignancies 
Stability and efficacy of pterostilbene nanoliposomes in cosmetic applications:A comprehensive study
《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期1-8,共8页Jianxin Li Heng Li Pengfei Ye Anlang Ou Manrong Liu Shiping Huang Yaoliang Jin 
supported by the Guangdong Provincial University Key Area Project[grant numbers 2023ZDZX4136];the Guangdong Provincial University Innovation Team Project[grant numbers 2023KCXTD085];the Guangdong Provincial Science and Technology Innovation Strategy Special Fund[grant numbers pdjh2022b1046];the Student Scientific Research Project of Jiangmen Polytechnic[grant numbers jzxsky20230102]。
Pterostilbene(PT),a lipid-soluble polyphenol known for its antioxidant,anticancer,and various other biological properties,holds potential as an active ingredient in cosmetics for its anti-wrinkle and skin-whitening ef...
关键词：PTEROSTILBENE Cosmetics Liposome nanoparticles Microjet homogenisation WHITENING TRANSDERMAL Efficacy evaluation 
Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
《Journal of Traditional Chinese Medical Sciences》2024年第3期316-329,共14页Xingshuang Song Yizhi Zhang Ziyan Tang Jing Dai Yanping Wu Guiyu Huang Hong Niu Yaxin Wang Xu Jin Lina Du 
supported by the National Natural Scientific Foundation(82172186);Beijing Natural Scientific Foundation(L222126).
Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used gi...
关键词：Post-traumatic stress disorder 6-GINGEROL Pressure sensitive adhesive patch Transdermal delivery 
Multichannel microneedle dry electrode patches for minimally invasive transdermal recording of electrophysiological signals被引量：1
《Microsystems & Nanoengineering》2024年第3期119-136,共18页Zhengjie Liu Xingyuan Xu Shuang Huang Xinshuo Huang Zhibo Liu Chuanjie Yao Mengyi He Jiayi Chen Hui-jiuan Chen Jing Liu Xi Xie 
support from the National Key R&D Program of China(Grant No.2021YFF1200700);the National Natural Science Foundation of China(Grant Nos.T2225010,32171399,32171456,62105380);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2023A1515011267,2023A1515111139);Science and Technology Program of Guangzhou,China(Grant No.2024B03J1284);the Opening Project of Key Laboratory of State Key Laboratory of Optoelectronic Materials and Technologies(OEMT-2022-ZRC-04);the Open Fund of the State Key Laboratory of Luminescent Materials and Devices(South China University of Technology,Grant No.2024-skllmd-11);Central Nervous System Drug Key Laboratory of Sichuan Province(Grant No.230036-01SZ).
The collection of multiple-channel electrophysiological signals enables a comprehensive understanding of the spatial distribution and temporal features of electrophysiological activities.This approach can help to dist...
关键词：NEEDLE RABBIT ELECTRODE 
Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy被引量：2
《Bioactive Materials》2024年第2期190-205,共16页Hui Xing Huanqi Peng Yuhui Yang Kai Lv Shihao Zhou Xiangjun Pan Jianjin Wang Yunfeng Hu Guowei Li Dong Ma 
financially supported by the National Natural Science Foundation of China(32171369 and 82102113);2023 cross-research project on basal research fund in central universities(21623410);the Jinan University-Honest Medical Joint Innovation Center(HX20220013);the Pre-study on transdermal technology and product development(ZX20220244)。
Androgenetic alopecia(AGA)is a common clinical condition,affecting over 200 million people globally each year.For decades,Minoxidil(Mi)tincture has been the primary treatment for this disease,but its low utilization r...
关键词：Nitric oxide Liposome Enhanced penetration Synergistic therapy Androgenetic alopecia 
Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial
《Stroke & Vascular Neurology》2024年第1期38-49,I0035-I0046,共24页Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath 
British Heart Foundation(grant number CS/14/4/30972);JPA is supported by an NIHR Health and Care Research Scholarship.PMB is Stroke Association Professor of Stroke Medicine and an NIHR Senior Investigator.TR is an NIHR Senior Investigator.GM is the Stroke Association Edith Murphy Foundation Senior Clinical Lecturer(SA L-SMP 18\1000).
Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is unclear.Here,we assess the safety and eff...
关键词：GLASGOW nitrate random 
Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species
《Bio-Design and Manufacturing》2024年第1期14-30,共17页Xinshuo Huang Baoming Liang Shantao Zheng Feifei Wu Mengyi He Shuang Huang Jingbo Yang Qiangqiang Ouyang Fanmao Liu Jing Liu Hui-jiuan Chen Xi Xie 
This work was financially supported by the National Key R&D Program of China(Nos.2021YFF1200700 and 2021YFA0911100);the National Natural Science Foundation of China(Nos.32171399,32171456,and T2225010);the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515012261);the Science and Technology Program of Guangzhou,China(No.202103000076);the Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22dfx02),and Pazhou Lab,Guangzhou(No.PZL2021KF0003);FML would like to thank the National Natural Science Foundation of China(Nos.32171335 and 31900954);JL would like to thank the National Natural Science Foundation of China(No.62105380);the China Postdoctoral Science Foundation(No.2021M693686);QQOY would like to thank the China Postdoctoral Science Foundation(No.2022M713645).
Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain an...
关键词：Microarrow sensor array Glucose sensing Reactive oxygen species sensing Integrated system Continuous monitoring 
Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis被引量：4
《Acta Pharmaceutica Sinica B》2023年第11期4417-4441,共25页Yuyi Xu Ming Zhao Jinxue Cao Ting Fang Jian Zhang Yanli Zhen Fangling Wu Xiaohui Yu Yaming Liu Ji Li Dongkai Wang 
supported by the Scientific Research Project of Liaoning Province Education Department (2020LJC16),China。
Rheumatoid arthritis is a chronic,systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate.Several drugs have been used for the treatment of rheumatoid arth...
关键词：Rheumatoid arthritis Transdermal drug delivery systems Different generations Enhancement strategies Drug therapy Transdermal delivery mechanism Advanced devices MICRONEEDLES 
Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery
《Research》2023年第2期139-157,共19页Jiaojiao Zhu Ruimin Chang Benliang Wei Yao Fu Xiang Chen Hong Liu Wenhu Zhou 
This work was supported by National Natural Science Foundation of China(Nos.U1903125,31800979);Natural ScienceFoundationof HunanProvinceinChina(2021JJ20084,2021J20092);the Science and Technology Innovation Program of Hunan Province(2021RC3020,2020RC2010);This study was also supported by National Key Research and Development Program of China(2019YFA0111600 and 2019YFE0120800);the Natural Science Foundation of China for Outstanding Young Scholars(82022060);the Youth Talent Program of Hunan Province(2019RS2009);the Natural Science Foundation of Hunan Province for Outstanding Young Scholars(2019JJ30040);Innovation-Driven Project of Central South University(2020CX043);China Postdoctoral Science Foundation Funded Project(2021M693558,2022T150741).
Immunotherapy has demonstrated the potential to cure melanoma,while the current response rate is still unsatisfactory in clinics.Extensive evidence indicates the correlation between the eficacy and pre-existing T-cell...
关键词：MELANOMA Antigen VACCINE 
3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations被引量：4
《Microsystems & Nanoengineering》2023年第2期127-142,共16页Xinshuo Huang Shantao Zheng Baoming Liang Mengyi He Feifei Wu Jingbo Yang Hui-jiuan Chen Xi Xie 
support from the National Key R&D Program of China(Grant No.2021YFF1200700,2021YFA0911100);National Natural Science Foundation of China(Grant No.32171399,32171456,T2225010);Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012261);Science and Technology Program of Guangzhou,China(Grant No.202103000076);Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(Grant No.22dfx02);Pazhou Lab,Guangzhou(Grant No.PZL2021KF0003);Opening Project of Key Laboratory of Microelectronic Devices&Integrated Technology,Institute of Microelectronics,Chinese Academy of Sciences,Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology,Key Laboratory of The Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province,Second Affliated Hospital of Zhejang University,School of Medicine(Grant.2022K02);State Key Laboratory Of Precision Measuring Technology And Instruments(Grant No.pilab2211);Open Funds of State Key Laboratory of Oncology in South China(Grant No.HN2022-01).
Monitoring human health is of considerable significance in biomedicine.In particular,the ion concentrations in blood are important reference indicators related to many diseases.Microneedle array-based sensors have ena...
关键词：needle SYSTEM BREAKTHROUGH 
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