Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder  

作　　者：Xingshuang Song Yizhi Zhang Ziyan Tang Jing Dai Yanping Wu Guiyu Huang Hong Niu Yaxin Wang Xu Jin Lina Du 

机构地区：[1]School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China [2]Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China [3]Information Department,General Hospital of Western War Zone,Chengdu 610083,China [4]Pharmaceutical College,Henan University,Kaifeng 475004,China [5]Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China [6]Cancer Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2024年第3期316-329,共14页中医科学杂志（英文）

基　　金：supported by the National Natural Scientific Foundation(82172186);Beijing Natural Scientific Foundation(L222126).

摘　　要：Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results: The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions: Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.

关 键 词：Post-traumatic stress disorder 6-GINGEROL Pressure sensitive adhesive patch Transdermal delivery 

分 类 号：R285[医药卫生—中药学] R283.6[医药卫生—中医学]