Stability and efficacy of pterostilbene nanoliposomes in cosmetic applications:A comprehensive study  

作　　者：Jianxin Li Heng Li Pengfei Ye Anlang Ou Manrong Liu Shiping Huang Yaoliang Jin 

机构地区：[1]Jiangmen Polytechnic,Guangdong Engineering and Technology Research Centre for Green and High-performance New Materials R&D,Jiangmen,Guangdong 529090,China [2]Weiyue(Jiangmen)Biotechnology Co.,Ltd.,Jiangmen,Guangdong 529090,China

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期1-8,共8页皮肤科学与化妆品技术期刊(英文)

基　　金：supported by the Guangdong Provincial University Key Area Project[grant numbers 2023ZDZX4136];the Guangdong Provincial University Innovation Team Project[grant numbers 2023KCXTD085];the Guangdong Provincial Science and Technology Innovation Strategy Special Fund[grant numbers pdjh2022b1046];the Student Scientific Research Project of Jiangmen Polytechnic[grant numbers jzxsky20230102]。

摘　　要：Pterostilbene(PT),a lipid-soluble polyphenol known for its antioxidant,anticancer,and various other biological properties,holds potential as an active ingredient in cosmetics for its anti-wrinkle and skin-whitening effects.However,its application is limited by its low water solubility and poor penetration through the stratum corneum.To address these limitations,this study initially prepared Pterostilbene nanoliposomes(PT-NLPs)using a high shear-microjet homogenization treatment method,because of the distinctive hydrophilic and hydrophilic properties of the liposomes.The stability under different storage conditions of the PT-NLPs was evaluated by investigating the alterations of the particle size,PDI,Zeta potential and surface morphology,combined with the test results of Lumisizer stability analyzer.Finally,the comprehensive performance of PT-NLPs was evaluated through in vitro dermal and transdermal testing,human testing,and instrument testing.The results showed that the PT-NLPs treated by the high shear-microjet homogenisation method proposed in this paper possessed a 1.7-fold increase in the retention performance compared with the free PT solution,and no penetration occurred on the blood-brain barrier,indicating that PT-NLPs would not cause toxicity to the organism.The human efficacy evaluation found that the PT-NLPs whitening serum could improve skin dullness,brighten skin tone,and improve skin sensitivity after 14 days of use.The high shear-microjet homogenisation method proposed in this paper for the treatment of PT-NLPs improved the transdermal delivery properties of PT.The process has a broad application prospect in the fields of medicine and cosmetics.

关 键 词：PTEROSTILBENE Cosmetics Liposome nanoparticles Microjet homogenisation WHITENING TRANSDERMAL Efficacy evaluation 

分 类 号：TQ658[化学工程—精细化工]