CASTANOSPERMINE

作品数：5被引量：5H指数：2
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相关领域：理学医药卫生更多>>
相关作者：钟捷徐一鸣周维善张洪禄更多>>
相关机构：中国科学院中国科学院大学淄博齐鼎立专利信息咨询有限公司更多>>
相关期刊：《合成化学》《Chinese Journal of Chemistry》《Chinese Chemical Letters》《World Journal of Transplantation》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Concise synthesis of 1-epi-castanospermine
《Chinese Chemical Letters》2017年第8期1688-1692,共5页Bin Cheng Yi-Xian Li Yue-Mei Jia Chu-Yi Yu 
Financial support from the National Natural Science Foundation of China(No.21272240);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104);National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University
1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive aminatio...
关键词：Reductive amination Synthesis Alkaloids Glycosidase inhibitors Polyhydroxylated indolizidines 
Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation被引量：2
《World Journal of Transplantation》2016年第1期206-214,共9页Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff 
Supported by Kiriwina Investments Limited of Australia
AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral cons...
关键词：Cardiac TRANSPLANTATION CASTANOSPERMINE CYCLOSPORIN A Positive INTERACTION Mixed LYMPHOCYTE reaction 
Design and concise synthesis of gem-difluoromethylenated analogue of 7-epi-castanospermine被引量：3
《Chinese Chemical Letters》2014年第8期1115-1120,共6页Xin-Yi Jiang Xiu-Hua Xu Feng-Ling Qing 
the National Natural Science Foundation of China (Nos. 21272036, 21332010);the National Basic Research Program of China (No. 2012CB21600)
A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-（-）-malic acid. The key steps involve substitution cyclization reaction and R...
关键词：lndolizidine CASTANOSPERMINE gem-Difluoromethylene CYCLIZATION DIHYDROXYLATION 
Asymmetric total synthesis of (+)-1-deoxy-6-epi-castanospermine
《Chinese Journal of Chemistry》1998年第1期34-44,共11页徐一鸣 周维善 
Project (29732061) supported by the National Natural Science Foundation of China and the State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
(+)-l-Deoxy-6-epi-castanospermine was asymmetrically synthesized in ten steps from a-furfuryl amine derivative 6 in 2.9% overall yield. The kinetic resolution of a-furfuryl mine derivative 6 and Sharpless AD reaction ...
关键词：Kinetic resolution total synthesis (+)-1-deoxy-6-epi-castanospermine 
1—Deoxy—6—epi—castanospermine的不对称全合成
《合成化学》1997年第A10期558-558,共1页徐一鸣 周维善 
关键词：Castanospermin 类似物 抗肿瘤药 
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