Design and concise synthesis of gem-difluoromethylenated analogue of 7-epi-castanospermine  

作　　者：Xin-Yi Jiang Xiu-Hua Xu Feng-Ling Qing 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science [2]College of Chemistry, Chemical Engineering and Biotechnology, Donghua University

出　　处：《Chinese Chemical Letters》2014年第8期1115-1120,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21272036, 21332010);the National Basic Research Program of China (No. 2012CB21600)

摘　　要：A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-（-）-malic acid. The key steps involve substitution cyclization reaction and RCM reaction to construct the aza fused bicyclic framework.A novel gem-difluoromethylenated castanospermine analogue B was designed and synthesized, starting from 3-bromo-3,3-difluoropropene and L-（-）-malic acid. The key steps involve substitution cyclization reaction and RCM reaction to construct the aza fused bicyclic framework.

关 键 词：lndolizidine CASTANOSPERMINE gem-Difluoromethylene CYCLIZATION DIHYDROXYLATION 

分 类 号：TQ464.4[化学工程—制药化工]