POLYMORPHISMS

作品数：634被引量：2320H指数：17
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Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis
《World Journal of Gastroenterology》2025年第7期156-159,共4页Shi Li Yue Xi Xue-Ying Dong Wen-Bin Yuan Jing-Feng Tang Ce-Fan Zhou 
Supported by National Natural Science Foundation of China,No.32270768,No.82273970,No.32070726,and No.82370715;National Key R&D Program of China,No.2023YFC2507904;the Innovation Group Project of Hubei Province,No.2023AFA026.
Hepatitis B virus remains a major cause of cirrhosis and hepatocellular carcinoma,with genetic polymorphisms and mutations influencing immune responses and disease progression.Nguyen et al present novel findings on sp...
关键词：Hepatitis B virus Gene polymorphisms Multi-clustering analysis Genetic markers Personalized medicine Clinical implications 
Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution
《World Journal of Gastrointestinal Oncology》2025年第1期101-109,共9页Mariarosaria D'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno 
BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD gene.About 7%of the European population is a carrier of DPYD gene polymorphisms associat...
关键词：Dihydropyrimidine dehydrogenase DPYD polymorphisms FLUOROPYRIMIDINE Caucasian population Gastrointestinal cancers 
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
《Cell Research》2024年第12期859-872,共14页Ting Zhao Xueying Guan Yan Hu Ziqian Zhang Han Yang Xiaowen Shi Jin Han Huan Mei Luyao Wang Lei Shao Hongyu Wu Qianqian Chen Yongyan Zhao Jiaying Pan Yupeng Hao Zeyu Dong Xuan Long Qian Deng Shengjun Zhao Mengke Zhang Yumeng Zhu Xiaowei Ma Zequan Chen Yayuan Deng Zhanfeng Si Xin Li Tianzhen Zhang Fei Gu Xiaofeng Gu Lei Fang 
This work was financially supported in part by grants from the Biological Breeding-Major Projects(2023ZD04076);the National Natural Science Foundation of China(32341024);Fundamental Research Funds for the Central Universities(226-2022-00100;226-2024-00205);the Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies.
DNA methylation plays multiple regulatory roles in crop development.However,the relationships of methylation polymorphisms with genetic polymorphisms,gene expression,and phenotypic variation in natural crop population...
关键词：breeding alone COTTON 
Association of miR-499 rs3746444,miR-149 rs2292832 polymorphisms and their expression levels with helicobacter pylori-related gastric diseases and Traditional Chinese Medicine syndromes
《Journal of Traditional Chinese Medicine》2024年第5期1024-1034,共11页LIU Qi YU Chang YE Jintong ZHANG Ling LI Danyan DAI Yunkai ZHANG Yunzhan LUO Qi CHEN Weijing PAN Huaigeng LI Ruliu HU Ling 
the National Natural Science Foundation of China:the Exploration of the Traditional Chinese Medicine Syndrome Characteristics During Benign and Malignant Pathological Evolution in Hp-Related Gastric Diseases from Wnt/β-catenin Signaling Pathway based on the Theory of"Evil Poison Lead to Change"(No.81774238);the Exploration of the Traditional Chinese Medicine Syndrome Characteristics During Benign and Malignant Pathological Evolution in Hp-Related Gastric Diseases based on the Theory of"Latent Toxin"and the Polymorphism and Expression of Mucosal Barrier Related Genes(No.82174298)。
OBJECTIVE:To provide an objective experimental basis for the gastric mucosa pathological evolution and the transformation of different Traditional Chinese Medicine(TCM)syndromes in helicobacter pylori(H.pylori)-relate...
关键词：MICRORNAS helicobacter pylori stomach diseases POLYMORPHISM genetic syndrome complex 
Genetic association analysis-based networks and classification of human UCP1 polymorphisms
《Genes & Diseases》2024年第3期63-65,共3页Donghai Li 
supported by the National Natural Science Foundation of China(No.31470716,310003233and 31070672);the Natural Science Foundation of Jiangsu Province,China(No.BK20131272).
Uncoupling protein 1(UCP1,also known as thermogenin or SLC25A7)plays an important role in the uncoupling of oxidative phosphorylation and adaptive non-shivering thermogenesis(NST).The genomic location for UCP1 is chro...
关键词：classification. UCP1 NETWORKS 
Nucleotide excision repair gene polymorphisms and hepatoblastoma susceptibility in Eastern Chinese children:A five-center case-control study
《Chinese Journal of Cancer Research》2024年第3期298-305,共8页Huimin Yin Xianqiang Wang Shouhua Zhang Shaohua He Wenli Zhang Hongting Lu Yizhen Wang Jing He Chunlei Zhou 
supported by grants from the Innovation and Cultivation Fund Project of the Seventh Medical Center,PLA General Hospital(No.QZX-2023-7);Postdoctoral Science Foundation of China(No.2021M691649);Postdoctoral Science Foundation of Jiangsu Province(No.2021K524C).
Objective:Nucleotide excision repair(NER)plays a vital role in maintaining genome stability,and the effect of NER gene polymorphisms on hepatoblastoma susceptibility is still under investigation.This study aimed to ev...
关键词：Nucleotide excision repair POLYMORPHISMS HEPATOBLASTOMA SUSCEPTIBILITY 
Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/Culex pipiens quinquefasciatus in China
《Infectious Diseases of Poverty》2024年第2期6-16,共11页Wenyu Li Delong Ma Qunzheng Mu Xinxin Zhou Dongdong Hua Chunchun Zhao Qiyong Liu Jun Wang Fengxia Meng 
funded by the National Science and Technology Major Project of China(No.2018ZX10101002-002)
Background Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease vectors.Long-term use of insecticides can cause mutations in the voltage-...
关键词：Culex pipiens pallens Culex pipiens quinquefasciatus vgsc gene MUTATION Frequency INTRON HAPLOTYPE China 
Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy
《Journal of Clinical and Nursing Research》2024年第2期220-227,共8页Min Zhang Rong Li Wei-guo Ma Xiao-hong Yin Ya Li 
Xi’an Science and Technology Bureau Fund(23YXYJ0103);Shaanxi Provincial Science and Technology Department Fund(S2022-YF-YBSF-0939).
Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 pat...
关键词：VISFATIN Diabetic retinopathy Single nucleotide polymorphism Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) 
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus被引量：1
《Acta Pharmaceutica Sinica B》2024年第2期437-454,共18页Jiamei Le Yilong Chen Wei Yang Ligong Chen Jianping Ye 
supported by grants from National Natural Science Foundation of China(81903961 to Jiamei Le,32271220 to Jianping Ye);National Key Research and Development Program of China(2020YFA0909000);National Natural Science Foundation of China(82127807);Shanghai Key Laboratory of Molecular Imaging(18DZ2260400,China);the Climbing Program of Shanghai University of Medicine and Health Sciences(A1-2601-23-311007,China).
Solute carriers(SLCs) constitute the largest superfamily of membrane transporter proteins.These transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of di...
关键词：Solute carriers(SLCs) Energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis POLYMORPHISMS 
Roles of the Apolipoprotein E Gene and Its Polymorphisms in the Etiopathophysiology of Type 2 Diabetes Mellitus and Its Atherosclerotic Complication in Senegalese Females
《Journal of Diabetes Mellitus》2023年第4期300-324,共25页Maïmouna Touré Fatou Diallo Agne Amadou Dieng Rokhaya Ndiaye Diallo Lamine Gueye Abdoulaye Samb 
Lipid metabolism disorders would be among the components responsible for the risk of the onset of T2DM and its vascular complications. Apolipoprotein E plays an important role in lipid metabolism. We studied the invol...
关键词：APOE Gene POLYMORPHISMS Type 2 diabetes Mellitus Vascular Dysfunctions 
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