Susceptible Genes and Polymorphisms Associated with Communicable and Noncommunicable Diseases  

作　　者：Mathew Folaranmi Olaniyan Ayowole Abraham Oladele Adelani Tijani Musa Abidemi Muhibi Tolulope Busayo Olaniyan 

机构地区：[1]Department of Medical Laboratory Science,Edo State University Uzairue,Uzairue,Nigeria [2]Department of Medical Laboratory Science,Lead City University,Ibadan,Ibadan,Nigeria [3]Department of Nursing Science,Federal University Oye Ekiti,Oye Ekiti,Nigeria

出　　处：《Journal of Bio-X Research》2024年第2期56-76,共21页生物组学研究杂志(英文)

摘　　要：Background:Disease epidemiology encompasses a wide range of health conditions,divided into communicable and noncommunicable diseases.Aim and Objective:This systematic review investigates the intricate connection between genetic susceptibility and disease development within these categories.Understanding genetic factors is crucial for improving prevention,diagnosis,and treatment strategies.The central research question is as follows:Which genes are linked to susceptibility to communicable and noncommunicable diseases,and how do these genetic elements affect susceptibility?We hypothesize that an exhaustive analysis of the literature will reveal numerous genes associated with both types of diseases,revealing the complex genetic landscape influencing susceptibility.Methodology:This systematic review follows a rigorous methodology,including comprehensive search strategies,well-defined inclusion and exclusion criteria,publication bias assessment,data extraction,quality evaluation,and data synthesis,adhering to PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses)guidelines to ensure transparency and ethical presentation.Several databases,including PubMed,Embase,Springer Nature,AJOL,CrossRef,Scopus,and Web of Science,were systematically searched to retrieve published articles.Findings:In communicable diseases,the genetic factors influencing susceptibility extend beyond well-established genes,warranting further investigation under conditions such as COVID-19,HIV,tuberculosis,and hepatitis B.Noncommunicable diseases,such as cardiovascular diseases,cancer,neurological disorders,and metabolic disorders,offer promising avenues for exploring additional genetic variations.Research gaps include understanding the functional impact of the identified polymorphisms,their interaction with environmental factors,and their implications for rare diseases.Conclusion:Genome-wide association studies and gene editing therapies have the potential to expand our understanding and therapeutic options for genetically based d

关 键 词：genome wide association studies communicable diseases genetic susceptibility genetic factors systematic review POLYMORPHISMS noncommunicable diseases 

分 类 号：R73[医药卫生—肿瘤]