FLUOROPYRIMIDINE

作品数：19被引量：51H指数：4
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Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution
《World Journal of Gastrointestinal Oncology》2025年第1期101-109,共9页Mariarosaria D'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno 
BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD gene.About 7%of the European population is a carrier of DPYD gene polymorphisms associat...
关键词：Dihydropyrimidine dehydrogenase DPYD polymorphisms FLUOROPYRIMIDINE Caucasian population Gastrointestinal cancers 
Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors
《World Journal of Gastrointestinal Oncology》2024年第2期251-254,共4页Mo-Wei Kong Feng-Di Sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-Fang Yang Guo-Xiang He 
In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:1031-1042.We specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related card...
关键词：CARDIOTOXICITY Gastrointestinal tumors Risk factors FLUOROPYRIMIDINE Chest pain 
DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug被引量：2
《Genes & Diseases》2023年第6期2557-2571,共15页Bingxue Yang Xinran Xie Zhaoyu Wu Dazhao Lv Jiajun Hu Yuyun Chen Jiaxing Li Shuyue Luo Jiacheng Li Jie Luo Shiyi Zhang 
supported by the Youth Thousand Talents Program of China,start-up grants from the Shanghai Jiao Tong University(No.WF220408211);supported by grants from the State Key Laboratory of Oncogenes and Related Genes(No.90-17-02)at Shanghai Jiao Tong University;from the Interdisciplinary Program of Shanghai Jiao Tong University(China)(No.YG2017MS18).
Hand-foot syndrome(HFS)is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes.Even though the cause and pathophysio...
关键词：Cellular senescence cGAS-STING Cutaneous toxicity DNA damage FLUOROPYRIMIDINE Hand-foot syndrome KERATINOCYTES Thymidine prodrug 
Review of 5-FU resistance mechanisms in colorectal cancer:clinical significance of attenuated on-target effects被引量：5
《Cancer Drug Resistance》2023年第2期257-272,共16页William H.Gmeiner Charles Chidi Okechukwu 
This research was supported by the National Cancer Institute of the National Institutes of Health under award R41 CA254834 A1(W.G.)P30 CA 012197;Department of Defense Peer Reviewed Cancer Research Program CA200460.Charles Chidi Okechukwu was supported in part by R41 CA254834 A1S1.
The emergence of chemoresistant disease during chemotherapy with 5-Fluorouracil-based(5-FU-based)regimens is an important factor in the mortality of metastatic CRC(mCRC).The causes of 5-FU resistance are multifactoria...
关键词：FLUOROPYRIMIDINE 5-FU resistance colorectal cancer CHEMOTHERAPY precision medicine thymidylate synthase 
New prognostic model for patients with advanced gastric cancer:Fluoropyrimidine/platinum doublet for first-line chemotherapy被引量：1
《World Journal of Gastroenterology》2021年第48期8357-8369,共13页Dong-Hoe Koo Min-Hee Ryu Mi-Yeon Lee Mee-Sun Moon Yoon-Koo Kang 
BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic model.AIM To develop a new model,MRGC patients ...
关键词：Stomach neoplasms CHEMOTHERAPY PROGNOSIS Validation Gastric cancer 
Fluoropyrimidine-induced cardiotoxicity被引量：3
《World Journal of Clinical Oncology》2020年第12期1008-1017,共10页Andrada Larisa Deac Claudia Cristina Burz Ioana Corina Bocsan Anca Dana Buzoianu 
Cardio-oncology is a discipline based on early screening,monitoring,and treating chemotherapy-induced cardiotoxicity.There are many chemotherapeutics known for their cardiac toxic effects,including fluoropyrimidines.F...
关键词：FLUOROPYRIMIDINES Cancer treatments CARDIOTOXICITY RECHALLENGE PREVENTION ANTIDOTE 
Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs被引量：1
《Cancer Drug Resistance》2019年第4期994-1001,共8页William H.Gmeiner 
Research reported in this publication was supported by the National Cancer Institute’s Cancer Center Support Grant(P30CA012197)issued to the Wake Forest Baptist Comprehensive Cancer Center.Gmeiner WH is supported by NIH grant(NIH-NCI R21 CA218933).
Topoisomerases are well-validated targets for cancer chemotherapy and DNA topoisomerase 1(Top1)is the sole target of the camptothecin(CPT)class of anticancer drugs.Over the last 20 years,multiple studies have shown To...
关键词：DNA topoisomerase 1 cancer chemotherapy CYTARABINE GEMCITABINE FLUOROPYRIMIDINE 
Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population被引量：1
《World Journal of Gastrointestinal Oncology》2019年第11期1031-1042,共12页Ka-On Lam Man-Chi Fu Kin-Sang Lau Kam-Mo Lam Cheuk-Wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying Ho To-Wai Leung Ho-Fun Lee 
BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective an...
关键词：CAPECITABINE 5-FLUOROURACIL CETUXIMAB METASTATIC COLORECTAL cancer Chinese 
Clinical significance of MET gene amplification in metastatic or locally advanced gastric cancer treated with first-line fluoropyrimidine and platinum combination chemotherapy被引量：7
《Chinese Journal of Cancer Research》2019年第4期620-631,共12页Seyoung Seo Min-Hee Ryu Baek-Yeol Ryoo Yangsoon Park Young Soo Park Young-Soon Na Chae-Won Lee Ju-Kyung Lee Yoon-Koo Kang 
supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (No. HI12C1785)
Objective: To investigate the clinical significance of MET gene amplification in patients with gastric cancer in the palliative setting.Methods: MET amplification was assessed using fluorescence in situ hybridization(...
关键词：MET amplification advanced GASTRIC cancer prognosis quantitative real-time POLYMERASE chain reaction 
CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients:promising findings from a prospective,open-label,randomized,phase III trial被引量：2
《Cancer Communications》2019年第1期258-270,共13页Yuankai Shi Jin Li Jianming Xu Yan Sun Liwei Wang Ying Cheng Wei Liu Guoping Sun Yigui Chen Li Bai Yiping Zhang Xiaohui He Yi Luo Zhehai Wang Yunpeng Liu Qiang Yao Yuhong Li Shukui Qin Xiaohua Hu Feng Bi Rongsheng Zheng Xuenong Ouyang 
Shanghai Zhangjiang Biotechnology Co.,Ltd.initiated and support this study;This work was also supported by the Chinese National Major Project for New Drug Innovation(2012ZX09101103,2013ZX09101002-001-001,and 2008ZX09312)
Background:The 5-fluorouracil/leucovorin plus oxaliplatin(FOLFOX)regimen is the standard first-line treatment for metastatic colorectal cancer(mCRC),however,the optimal second-line regimen for KRAS wild-type mCRC pati...
关键词：CMAB009 Cetuximab IRINOTECAN SECOND-LINE mCRC EGFR KRAS Immunogenicity FLUOROPYRIMIDINE Oxaliplatin failure 
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