POLYMERASE

作品数：459被引量：1086H指数：15
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Atractylenolide Ⅰ ameliorates post-infectious irritable bowel syndrome by inhibiting the polymerase Ⅰ and transcript release factor and c-Jun N-terminal kinase/inducible nitric oxide synthase pathway
《Journal of Traditional Chinese Medicine》2025年第1期57-65,共9页YUAN Jianan CHENG Kunming LI Chao ZHANG Xiang DING Zeyu LI Bing ZHENG Yongqiu 
The University Collaborative Innovation Project of Anhui:Creation of a Combined Animal Model of Coronary Heart Disease based on the Theory of Xin'an Medicine(No.GXXT-2020-024);Start-up Funding for Doctoral Research at Wannan Medical College(WYRCQD2018009);Horizontal Project of South Anhui Medical College(H202003)。
OBJECTIVE:To explore the therapeutic effect and target of atractylenolide I(AT-I)on post-infectious irritable bowel syndrome(PI-IBS)rats.METHODS:Therefore,the preliminarily mechanism of AT-I in anti-PI-IBS were first ...
关键词：atractylenolideⅠ post-infectious irritable bowel syndrome polymeraseⅠand transcript release factor network pharmacology MAP kinase signaling system nitric oxide synthase typeⅡ 
Synergistic effect of poly(ADP-ribose)polymerase(PARP)inhibitor with chemotherapy on CXorf67-elevated posterior fossa group A ependymoma
《Chinese Medical Journal》2024年第22期2770-2772,共3页Jichang Han Jianzhong Yu Meng Yu Yachao Liu Xiaomin Song Hao Li Lin Li 
supported by grants from the National Natural Science Foundation of China(Nos.92253303,92053201,and 82103123);the National Key Research and Development Program of China(No.2019YFA0802002);the China Postdoctoral Science Foundation(No.2021M703208).
To the Editor:Posterior fossa group A(PFA)ependymoma is one of the most common and aggressive pediatric tumors,which currently lacks effective chemotherapies.[1,2]Previously,we revealed CXorf67,which is specially unre...
关键词：drugs ELEVATED RENDER 
Rapid detection of the rice false smut fungus Ustilaginoidea virens by lateral flow strip-based recombinase polymerase amplification assay
《Journal of Integrative Agriculture》2024年第11期3763-3773,共11页Jiacheng Xi Sanlian Wan Yue Li Yuandi Xu Jing Yang Ting Zhang Jiajia Chen Zhengguang Zhang Danyu Shen Haifeng Zhang 
supported by grants from the Jiangsu Agricultural Science and Technology Innovation Fund,China(JASTIF)(CX(21)3012)to Haifeng Zhang。
Rice false smut,caused by Ustilaginoidea virens,is a devastating disease that greatly reduces rice yield and quality.However,controlling rice false smut disease is challenging due to the unique infection mode of U.vir...
关键词：rice false smut Ustilaginoidea virens isothermal amplification disease monitoring field diagnosis 
Bibliometric analysis of olaparib and pancreatic cancer from 2009 to 2022:A global perspective
《World Journal of Gastrointestinal Oncology》2024年第11期4489-4505,共17页Xu Feng Yi-Han Chai Ke-Xin Jiang Wen-Bin Jiang Wen-Chao Chen Yu Pan 
the Zhejiang Provincial Medical and Health Science and Technology Program,No.2024KY1109.
BACKGROUND Genetic screening for breast cancer gene 1(BRCA)1/2 mutations can inform breast/ovarian/pancreatic cancer patients of suitable therapeutic interventions.Four to seven percent of pancreatic cancer patients h...
关键词：OLAPARIB Pancreatic cancer Bibliometric analysis Breast cancer susceptibility gene Poly(adenosine diphosphate-ribose)polymerase 
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta(POLE/POLD1)mutation
《Signal Transduction and Targeted Therapy》2024年第10期4543-4553,共11页Ying Jin Run-Jie Huang Wen-Long Guan Zhi-Qiang Wang Zong-Jiong Mai Yu-Hong Li Jian Xiao Xing Zhang Qi Zhao Shi-Fu Chen Ming Liu Yan-Xia Shi Feng Wang Rui-Hua Xu 
National Natural Science Foundation of China(82321003,81930065,82173128);CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-036);Science and Technology Program of Guangzhou(202206080011);Medical Scientific Research Foundation of Guangdong Province(A2022054);Cancer Innovative Research Program of Sun Yat-sen University Cancer Center(CIRP-SYSUCC-0004);Sun Yat-sen University Clinical Research 5010 Program(84000-31630002);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(22yklj06);Young Talents Program of Sun Yat-sen University Cancer Center(YTP-SYSUCC-0018);CSCO foundation(Y-QL202202-0089).
Patients carrying mutations in polymerase epsilon/polymerase delta have shown positive responses to immune checkpoint inhibitors.Yet,prospective trials exploring the efficacy in those with polymerase epsilon/polymeras...
关键词：DELTA phase NEITHER 
A recombinase polymerase amplification with lateral flow assay for rapid on-the-spot detection of Aeromonas salmonicida
《Water Biology and Security》2024年第3期58-64,共7页Sijie Zhang Yuanxing Zhang Qin Liu Qiyao Wang Yibei Zhang 
financially supported by National Key Research and Development Program of China(2022YFE0101200);National Natural Science Foundation of China(32102850);Shanghai Agricultural Science and Technology Innovation Project(T2023328).
Aeromonas salmonicida is a common pathogen of salmonid fishes that poses a significant threat to the fresh water and marine culture industry,potentially resulting in huge economic losses.To prevent and control fish di...
关键词：Aeromonas salmonicida Recombinase Polymerase Amplification(RPA) Lateral flow On-the-spot detection 
Role of feline ANP32 proteins in regulating polymerase activity of influenza A virus
《Journal of Integrative Agriculture》2024年第9期3145-3158,共14页Gang Lu Feiyan Zheng Yuqing Xiao Ran Shao Jiajun Ou Xin Yin Shoujun Li Guihong Zhang 
supported by the National Natural Science Foundation of China(32172826).
Recently,increasing natural infection cases and experimental animal challenge studies demonstrated domestic cats are susceptible to multiple subtypes influenza A virus(IAV)infections.Notably,some subtype IAV strains c...
关键词：ANP32 influenza A virus FELINE cross-species transmission 
AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase被引量：1
《Virologica Sinica》2024年第4期632-644,共13页Junrui Ren Lei Yu Qiuhan Zhang Pengyu Ren Yumeng Cai Xueyun Wang Ke Lan Shuwen Wu 
supported by National Natural Science Foundation of China(32188101 and 81971976).
Hand,foot and mouth disease(HFMD),mainly caused by enterovirus 71(EV71),has frequently occurred in the Asia-Pacific region,posing a significant threat to the health of infants and young children.Therefore,research on ...
关键词：AIMP2 Enterovirus 71(EV71) 3D polymerase E3 ligase SMURF2 UBIQUITINATION 
M1磁珠富集联合重组酶介导的聚合酶链式反应技术检测肺炎克雷伯菌
《中国科技期刊数据库 医药》2024年第8期147-152,共6页张盼盼 帖彦清 
一直以来,人类健康都在承受着病原微生不同程度的威胁,其中肺炎克雷伯菌是常见的条件致病菌之一,当机体免疫力低下时,容易发生炎性病变,从而引起肺炎、尿路感染和败血症等院内感染。综合分析肺炎克雷伯菌的致病特征,认为快速、准确地从...
关键词：肺炎克雷伯菌 M1磁珠 重组酶介导 聚合酶链式反应 (polymerase CHAIN reaction PCR) 
Development of a multiplex recombinase polymerase amplification coupled with lateral flow dipsticks for the simultaneous rapid detection of Salmonella spp.,Salmonella Typhimurium and Salmonella Enteritidis
《Food Quality and Safety》2024年第2期302-311,共10页Zeqiang Zhan Shoukui He Yan Cui Jinzeng Yang Xianming Shi 
supported by the National Key R&D Program of China(No.2019YFE0119700);the National Natural Science Foundation of China(No.32172316).
Objectives:Salmonella spp.is a world-leading foodborne pathogen and its rapid detection is essential for ensuring food safety.Conventional methods require expensive instruments,considerable operational skills and cann...
关键词：SALMONELLA multiplex detection lateral flow dipstick recombinase polymerase amplification meat product 
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