FLUOROPYRIMIDINES

作品数：6被引量：7H指数：1
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Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer:a post hoc analysis of the AXEPT study被引量：1
《Cancer Communications》2023年第4期519-522,共4页Satoru Iwasa Zi-Xian Wang Kei Muro Satoshi Morita Young Suk Park Dongsheng Zhang Yasuhide Yamada Junichi Sakamoto TaeWon Kim 
Dear Editor,Recently,the phase III Asian XELIRI(capecitabine plus irinotecan)ProjecT(AXEPT)study demonstrated the non-inferiority of modified capecitabine plus irinotecan(mXELIRI)±bevacizumab(Bev)to fluorouracil plus...
关键词：FOLFIRI colorectal METASTATIC 
Fluoropyrimidine-induced cardiotoxicity被引量：3
《World Journal of Clinical Oncology》2020年第12期1008-1017,共10页Andrada Larisa Deac Claudia Cristina Burz Ioana Corina Bocsan Anca Dana Buzoianu 
Cardio-oncology is a discipline based on early screening,monitoring,and treating chemotherapy-induced cardiotoxicity.There are many chemotherapeutics known for their cardiac toxic effects,including fluoropyrimidines.F...
关键词：FLUOROPYRIMIDINES Cancer treatments CARDIOTOXICITY RECHALLENGE PREVENTION ANTIDOTE 
Tailored therapy in patients treated with fluoropyrimidines: focus on the role of dihydropyrimidine dehydrogenase
《Cancer Drug Resistance》2019年第3期787-802,共16页Filippo Merloni Nicoletta Ranallo Laura Scortichini Riccardo Giampieri Rossana Berardi 
Fluoropyrimidines are widely used in the treatment of solid tumors, mainly gastrointestinal, head and neck and breast cancer. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for catabolism of 5-FU an...
关键词：5-FLUOROURACIL FLUOROPYRIMIDINES CHEMOTHERAPY dihydropyrimidine dehydrogenase dihydropyrimidine dehydrogenase DPYD CPIC POLYMORPHISMS 
The use of pharmacogenetics to increase the safety of colorectal cancer patients treated with fluoropyrimidines被引量：1
《Cancer Drug Resistance》2019年第1期116-130,共15页Elena De Mattia Rossana Roncato Chiara Dalle Fratte Fabrizio Ecca Giuseppe Toffoli Erika Cecchin 
Fluoropyrimidines(FP)are given in the combination treatment of the advanced disease or as monotherapy in the neo-adjuvant and adjuvant treatment of colorectal cancerand other solid tumors including breast,head and nec...
关键词：FLUOROPYRIMIDINES PHARMACOGENETICS colorectal cancer toxicity DPYD TYMS MTHFR 
Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitriles and the Related Derivatives as Photochemical Probe Agents for Inhibition of Vitiligo Disease被引量：1
《International Journal of Organic Chemistry》2012年第3期311-320,共10页Mohammed S. T. Makki Dina A. Bakhotmah Reda M. Abdel-Rahman Mohammed S. El-Shahawy 
A new biocidal agents fluorine substituted-3-thioxopyrimidine-5-carbonitriles (2-9) and/or the related fluorine substi- tuted pyrimido (4,5-d) pyrimidines (10-14) were synthesized by the cycloaddition of fluorinated ...
关键词：Synthesis FLUOROPYRIMIDINES PHOTOCHEMICAL Probes 
A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer被引量：1
《Journal of Cancer Therapy》2012年第6期989-995,共7页Masanori Hotchi Hiroshi Okitsu Murato Miura Madoka Hamada Yasuhide Sonaka Yoh Fukuda Tsutomu Ando Shinji Kuratate 
Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of disease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral dihydropyrimidi...
关键词：S-1 UFT CHEMORADIATION RECTAL Cancer 
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