Genetic association analysis-based networks and classification of human UCP1 polymorphisms  

作　　者：Donghai Li 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Jiangsu 210023,China

出　　处：《Genes & Diseases》2024年第3期63-65,共3页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.31470716,310003233and 31070672);the Natural Science Foundation of Jiangsu Province,China(No.BK20131272).

摘　　要：Uncoupling protein 1(UCP1,also known as thermogenin or SLC25A7)plays an important role in the uncoupling of oxidative phosphorylation and adaptive non-shivering thermogenesis(NST).The genomic location for UCP1 is chromosome 4 q31.1:140,555,770--140,568,961(GRCh38/hg38)and its size is 13,192 bases split into 6 exons.In dbSNP,3650 short genetic variations of human UCP1 are documented.In this study,UCP1 serves as an example to construct polymorphism-trait networks and enable a func-tional classification.

关 键 词：classification. UCP1 NETWORKS 

分 类 号：R394[医药卫生—医学遗传学]