Objective To evaluate the efficacy and safety of roxadustat in patients with refractory non-severe aplastic anemia (NSAA).Methods The clinical data of patients with refractory NSAA who had been treated with roxadustat...
Objective To explore the distribution of Chinese medicine (CM) syndromes of children with non-severe aplastic anemia (NSAA),and to provide reference for CM clinical sydrome differentiation and classification of NSAA.
supported by grants from the Innovative Clinical Technique of Guangzhou,China(No.2019GX04 and 2023C-GX01 to YPZ and SQW,respectively);2019 Annual Research Project of The China Marrow Donor Program(No.CMDP201902 to SQW);Guangzhou Municipal Science and Technology project(China)(No.202002030035 to SQW);the Natural Science Foundation of Guangdong Province,China(No.2018A0303130179 to MZ).
Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone mar...
Objective To analyze the diagnostic value of cellfree plasma metagenomic next-generation sequencing(mNGS)pathogen identification for severe aplastic anemia(SAA)bloodstream infection.Methods From February 2021 to Febru...
Supported by The Specialized Scientific Research Fund Projects of The Medical Group of Qingdao University,No.YLJT20201002.
BACKGROUND Myelodysplastic syndrome(MDS)is caused by malignant proliferation and ineffective hematopoiesis.Oncogenic somatic mutations and increased apoptosis,necroptosis and pyroptosis lead to the accumulation of ear...
Supported by The Specialized Scientific Research Fund Projects of The Medical Group of Qingdao University,No.YLJT20201002.
BACKGROUND Myelodysplastic syndrome(MDS)is a hematological neoplasm,and an increase in myeloblasts is representative of leukemic hematopoiesis in advanced MDS.Lowrisk MDS usually exhibits deranged autoimmunity resembl...
Chimeric antigen receptor(CAR)T-cell therapy is an effective new treatment strategy for hematologic malignancies.The success of CAR T-cell therapy in treating leukemia and lymphoma has promoted its development for mul...
Acquired aplastic anemia(AAA)is an auto-immune disease(AID)resulting from aberrant T-cell-mediated and antigen-driven immune responses to hematopoietic stem and progenitor cells(HSPCs)in genetically susceptible indivi...
Objective To investigate the efficacy of alternative donor(AD)in the treatment of aplastic anemia(AA)in children.Methods The clinical data of AA children who received AD HSCT in our center from Apr.2010 to Dec.2016 we...