Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia  

作　　者：Cunte Chen Yuling Zhang Dongpei Lu Zelong Zhang Jun Yang Xiaowei Chen Ming Zhou Wenjian Mo Caixia Wang Qinghua Cai Yumiao Li Ruiqing Zhou Shilin Xu Wei Zhou Tingfen Deng Shiyi Pan Yanli Xu Shunqing Wang Yuping Zhang 

机构地区：[1]Department of Hematology,Guangzhou First People's Hospital,South China University of Technology,Guangzhou,Guangdong 510180,China [2]Guangzhou Junruikang Biotechnology Co.,Ltd,Guangzhou,Guangdong 510700,China

出　　处：《Genes & Diseases》2024年第1期95-98,共4页基因与疾病（英文）

基　　金：supported by grants from the Innovative Clinical Technique of Guangzhou,China(No.2019GX04 and 2023C-GX01 to YPZ and SQW,respectively);2019 Annual Research Project of The China Marrow Donor Program(No.CMDP201902 to SQW);Guangzhou Municipal Science and Technology project(China)(No.202002030035 to SQW);the Natural Science Foundation of Guangdong Province,China(No.2018A0303130179 to MZ).

摘　　要：Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone marrow(BM)cells,putative autoantigens,and oligoclonal expansion of CD8+T cells.1 For SAA patients,the definitive therapies are immunosuppressive therapy(IST)or hematopoietic stem transplantation(HSCT).

关 键 词：ANEMIA APLASTIC INTERFERON 

分 类 号：R392[医药卫生—免疫学]