Geraniol alleviates cyclophosphamide-induced cardiotoxicity in mice  

作　　者：Shahid Karim Rasheed A.Shaik 

机构地区：[1]Department of Clinical Pharmacology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia [2]Department of Pharmacology and Toxicology,Faculty of Pharmacy,King Abdulaziz University,Jeddah,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第10期427-435,共9页亚太热带生物医学杂志（英文版）

基　　金：The Deanship of Scientific Research at King Abdulaziz University,Jeddah,Saudi Arabia has funded this project under grant no.RG-21-166-43.

摘　　要：Objective:To explore the effect of geraniol on cyclophosphamide-induced cardiotoxicity.Methods:Mice were divided into five groups:the control group,the cyclophosphamide group(200 mg/kg cyclophosphamide,i.p.on day 7),the group treated with geraniol 100 and 200 mg/kg from day 1 to day 14,along with a single dose of cyclophosphamide on day 7,and the geraniol alone group(200 mg/kg geraniol from day 1 to day 14).At the end of the study,animals were sacrificed,and blood and heart were collected and analyzed for biochemical,histopathological,and immunohistochemical changes.Results:Treatment with 200 mg/kg geraniol significantly reduced the levels of cardiac injury markers,malondialdehyde,and inflammatory and apoptotic markers,while increasing antioxidant activities in mice with cyclophosphamide-induced cardiotoxicity.Moreover,it remarkably alleviated histopathological aberrations in cardiac tissue.Conclusions:Geraniol attenuates cyclophosphamide-induced cardiotoxicity via antioxidant,anti-inflammatory,and antiapoptotic effects.

关 键 词：GERANIOL CARDIOTOXICITY Natural product CYCLOPHOSPHAMIDE INFLAMMATION APOPTOSIS 

分 类 号：R965[医药卫生—药理学]