Focus on cardiac troponin complex:From gene expression to cardiomyopathy  

作　　者：Rosetta Ragusa Chiara Caselli 

机构地区：[1]Institute of Clinical Physiology,CNR,via Moruzzi 1,Pisa 56124,Italy [2]Fondazione Toscana Gabriele Monasterio,via Moruzzi 1,Pisa 56124,Italy

出　　处：《Genes & Diseases》2024年第6期115-134,共20页基因与疾病（英文）

摘　　要：The cardiac troponin complex(cTn)is a regulatory component of sarcomere.cTn consists of three subunits:cardiac troponin C(cTnC),which confers Ca2+sensitivity to muscle;cTnl,which inhibits the interaction of cross-bridge of myosin with thin filament during dias-tole;and cTnT,which has multiple roles in sarcomere,such as promoting the link between the cTnl-cTnC complex and tropomyosin within the thin filament and influencing Ca2+sensi-tivity of cTn and force development during contraction.Conditions that interfere with inter-actions within cTn and/or other thin filament proteins can be key factors in the regulation of cardiac contraction.These conditions include alterations in myoflament Caz+sensitivity,direct changes in cTn function,and triggering downstream events that lead to adverse cardiac remodeling and impairment of heart function.This review describes gene expression and post-translational modifications of cTn as well as the conditions that can adversely affect the deli-cate balance among the components of cTn,thereby promoting contractile dysfunction.

关 键 词：Cardiac troponin CARDIOMYOPATHY Genemutation Post-translational modification THERAPY 

分 类 号：R542.2[医药卫生—心血管疾病]