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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis被引量：1: 《Cellular & Molecular Immunology》2023年第10期1140-1155,共16页Abrar Ul Haq Khan Alaa Kassim Ali Bryan Marr Donghyeon Jo Simin Ahmadvand Claire Fong-McMaster Saeedah Musaed Almutairi Lisheng Wang Subash Sad Mary-Ellen Harper Seung-Hwan Lee; Natural killer(NK)cells are predominant innate lymphocytes that initiate the early immune response during infection.NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infectio...; 关键词：Natural killer cells TNFA TNFR2 GLYCOLYSIS PROLIFERATION Murine cytomegalovirus

畅枢汤在大鼠痤疮模型中对TLR4/TNFa/IL-1信号通路和CK10的影响: 《河南预防医学杂志》2022年第10期761-767,共7页卢改会朱克彬李涛; 河南省自然科学基金(212300410190);河南省中医药科学研究专项课题(2019JDZX2029)。; 目的探索畅枢汤在大鼠痤疮模型中,对TLR4/TNFa/IL-1信号通路和角化标志物CK10的影响。方法构建大鼠痤疮模型,实验组给予畅枢汤7.71 g/(kg·d)灌胃给药,对照组分别给予异维A酸胶囊3.125 mg/(kg·d)及畅枢汤+异维酸胶囊灌胃给药,设立空...; 关键词：大鼠痤疮模型畅枢汤 TLR4/TNFa/IL-1 CK10

Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis被引量：1: 《Genes & Diseases》2022年第1期140-150,共11页Chun Xing Duo Jiang Yang Liu Qiqun Tang Haiyan Huang; This research was supported by National Natural Science Foundation(No.81770844,82070870 and 81170781 to H.Y.Huang).; Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure,ultimately reducing adiposity.Here,we report the central role of adipocyte-derived l...; 关键词：Adaptive thermogenesis BAT Beige fat Lysyl oxidase TNFA

Therapeutic potential of TNFa inhibitors in chronic inflammatory disorders:Past and future被引量：1: 《Genes & Diseases》2021年第1期38-47,共10页future Hongtao Zhang Nelson Shi Zhuo Diao Youhai Chen Yejia Zhang; the Department of Veterans Affairs Healthcare Network,a Penn Center for Musculoskeletal Disorders(PCMD)pilot grant(P30-AR050950-10 Pilot);a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS,R21 AR071623).; In the past 20 years,patients with rheumatoid arthritis(RA),Crohn’s disease(CD),and other immune diseases have witnessed the impact of a great treatment advance with the availability of biological TNFa inhibitors.Wit...; 关键词：ANTIBODIES RECEPTORS Small molecule inhibitors TNFA TNFR1

尤瑞克林对局灶性脑缺血再灌注大鼠脑组织NF-κB、TNFa的影响及治疗效果探究被引量：2: 《神经解剖学杂志》2018年第5期585-590,共6页杨美丽洪志林蔡若蔚叶励超陈雅芳王凌星; 福建省卫计委青年科研课题(2014-1-65);福建医科大学青年苗圃科研基金项目(2014MP032);福建省教育厅中青年教师教育科研项目(JAT160193);福建医科大学附属第二医院科研骨干基金项目(2016MP08); 目的:探索尤瑞克林注射液对大脑中动脉缺血再灌注损伤大鼠的影响。方法:54只SD大鼠随机分成3组:假手术组、线栓组和治疗组。线检法建立大鼠大脑中动脉闭塞后再灌注模型,通过缺血2 h后拔出线栓恢复血流再灌注24 h。比较脑梗塞体积和神经...; 关键词：脑缺血再灌注核因子ΚB 肿瘤坏死因子-α 尤瑞克林大鼠

儿童肺炎与TNFa的相关性研究: 《中国优生与遗传杂志》2017年第12期125-127,共3页张莉马琳安会波张建伟刘征燕葛胜旺刘玲王凌燕; 课题项目名称:空气污染诱发儿童呼吸道疾病的早期诊断与精准化治疗; 目的探讨儿童肺炎与TNFa的相关性。方法采用序列特异性引物—聚合酶链反应(SSP/PCR)对265例肺炎患儿和265例随机来院体检的健康儿童TNFa的5个等位基因进行分析,计算各个位点的基因分布频率,并进行卡方检验,肺炎组与对照组之间进行逐个...; 关键词：肺炎 TNFA 儿童基因

Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)polymorphisms with protection and susceptibility to dengue in Brazilian population: 《Asian Pacific Journal of Tropical Medicine》2017年第11期1065-1071,共7页Ana Caroline Melo dos Santos Edilson Leite de Moura Jean Moises Ferreira Alexandre Wendell Araujo de Moura Ailson Darlan Sales Ferreira Rubens Pereira Bezerra Diego de Siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia Martins de Souza Figueiredo; supported by the Fundacao de Amparo a Pesquisa de Alagoas(FAPEAL)–Programa Primeiros Projetos(PPP/2011); Objective: To evaluate gene polymorphisms and their association with susceptibility to dengue.Methods: A retrospective case-control study was performed with 262 subjects,comprising 78 dengue fever(DF) patients, 49 den...; 关键词：Immune system IFNG TNFA IL-10 DENGUE POLYMORPHISM

过表达MicroRNA-199a促进TNFα诱导的脂肪细胞凋亡被引量：1: 《生物技术通报》2017年第3期180-185,共6页齐仁立王琪吴永江王敬黄金秀杨飞云; 国家自然科学基金项目(31470117;31302055);重庆市畜牧科学院基本科研业务费项目(14403); 旨为探明micro RNA-199a(mi R-199a)对脂肪细胞凋亡的影响及核转录因子κB(nuclear factorκB,NF-κB)在其中的作用。培养3T3-L1脂肪细胞,使用肿瘤坏死因子α(tumor necrosis factorα,TNFα)诱导细胞凋亡。在此基础上分别使用NF-κB阻...; 关键词：MI R-199a 脂肪细胞凋亡 TNFA NF-ΚB

Mechanism underlying berberine's effects on HSP70/TNFα under heat stress:Correlation with the TATA boxes被引量：8: 《Chinese Journal of Natural Medicines》2017年第3期178-191,共14页JIANG Jing-Fei LEI Fan YUAN Zhi-Yi WANG Yu-Gang WANG Xin-Pei YAN Xiao-Jin YU Xuan XING Dong-Ming DU Li-Jun; supported by the National Natural Science Foundation of China(Nos.81374006,90713043 and 81073092); Heat stress can stimulate an increase in body temperature, which is correlated with increased expression of heat shock protein 70 （HSP70） and tumor necrosis factor a （TNFa）. The exact mechanism underlying the HSP7...; 关键词：BERBERINE HYPERTHERMIA HSP70 TNFA TATA box

DC Maturation: A Brief Comparison between Three Different Processes: 《Journal of Cancer Therapy》2015年第10期871-880,共10页Maria Toloudi Ioannis Papasotiriou; Dendritic cell (DC) maturation approved to be a pivotal process for initiating immunity. Many protocols were established in order the isolated peripheral blood mononuclear cells (PBMCs) from healthy donors to mature i...; 关键词：DC MATURATION TNFA IL-4 IFNa

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