Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis  

作　　者：Chun Xing Duo Jiang Yang Liu Qiqun Tang Haiyan Huang 

机构地区：[1]Key Laboratory of Metabolism and Molecular Medicine,The Ministry of Education,Department of Biochemistry and Molecular Biology,Fudan University School of Basic Medical Sciences,Shanghai 200032,PR China

出　　处：《Genes & Diseases》2022年第1期140-150,共11页基因与疾病（英文）

基　　金：This research was supported by National Natural Science Foundation(No.81770844,82070870 and 81170781 to H.Y.Huang).

摘　　要：Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure,ultimately reducing adiposity.Here,we report the central role of adipocyte-derived lysyl oxidase(Lox)in the formation of thermogenic beige fat.Mice exposed to cold or aβ3 agonist showed drastically lower Lox expression in thermogenically activated beige fat.Importantly,inhibition of Lox activity with BAPN stimulated biogenesis of beige fat in inguinal white adipose tissue(iWAT)under housing conditions and potentiated cold-induced adaptive thermogenesis and beiging in both iWAT and epididymal white adipose tissue(eWAT).Notably,white adipocytes with Lox repression undergo transdifferentiation into beige adipocytes which can be suppressed by tumor necrosis factor-α(TNFα)via ERK activation.This work provides new insight into the molecular control to expand beige fat by Lox inhibition and suggest the potential for utilizing inhibitor of Lox to treat the emerging epidemics of obesity and diabetes.

关 键 词：Adaptive thermogenesis BAT Beige fat Lysyl oxidase TNFA 

分 类 号：R589.2[医药卫生—内分泌]