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ANTIBODIES: 作品数：753被引量：1558H指数：17; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：谭立明史秋梅高光平张艳英曾淑君更多>>; 相关机构：中国人民解放军南京军区北京协和医院重庆医科大学附属第一医院中国药科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders: 《Neural Regeneration Research》2025年第4期1085-1086,共2页Charis Ma Krystyna Rytel Yu Chen Ellen Sidransky; In medical research,there are times when the introduction of a new tool can launch scientific discovery in new directions.While antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)r...; 关键词：ANTIBODIES cerebro

Combining anti-PD-1 antibodies with surufatinib for gastrointestinal neuroendocrine carcinoma: Two cases report and review of literature: 《World Journal of Clinical Oncology》2025年第4期298-311,共14页Lou-Lu Gao Dong-Ni Gao Hong-Tu Yuan Wen-Qiang Chen Jing Yang Jie-Qiong Peng; BACKGROUNDGastrointestinal neuroendocrine carcinoma (GI NEC) has a low incidence rate andpoor prognosis. Most patients already have metastatic disease when they arediagnosed. Platinum chemotherapy is the main means of...; 关键词：Gastrointestinal neuroendocrine carcinoma Immune checkpoint inhibitors Angiogenesis inhibitors Combination therapy Case report

Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic: 《World Journal of Virology》2025年第1期99-107,共9页Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M F Antunes Mônica C Carneiro Fabio S Ronzei Julia C Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves; BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory issues.Thi...; 关键词：Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19

AI-driven antibody design with generative diffusion models:current insights and future directions: 《Acta Pharmacologica Sinica》2025年第3期565-574,共10页Xin-heng He Jun-rui Li James Xu Hong Shan Shi-yi Shen Si-han Gao H.Eric Xu; supported by the Lingang Laboratory,Grant No.LG-GG-202204-01;the National Natural Science Foundation(82121005,32130022);CAS Strategic Priority Research Program(XDB37030103);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02).; Therapeutic antibodies are at the forefront of biotherapeutics,valued for their high target specificity and binding affinity.Despite their potential,optimizing antibodies for superior efficacy presents significant cha...; 关键词：ANTIBODIES generative model diffusion de novo antibody design CDR optimization model evaluation

Adolescent-Onset Triple-Antibody Positive Juvenile Dermatomyositis Found in Hispanic Male Wrestler: A Case Report and Literature Review: 《Open Journal of Rheumatology and Autoimmune Diseases》2025年第1期36-42,共7页Rajvee Sanghavi Patrycja Tesmer Deepika Singh Sukesh Sukumaran; In this manuscript, we present a case report of a child with 16-year-old previously healthy Hispanic male who presented for progressive proximal muscle weakness, rash, and dysphagia. He was admitted to the acute care ...; 关键词：Juvenile Dermatomyositis Myositis-Associated Antibodies Myositis-Specific Antibodies

TransTACs:Transforming antibodies into targeted protein degraders: 《Acta Pharmaceutica Sinica B》2025年第2期1186-1188,共3页Yu Guo Jinxin Che Xiaowu Dong; Over the past two decades,proteolysis-targeting chimeras(PROTACs)have gradually evolved from chemical biology tools into potential clinical candidates,marking a significant advancement in our ability to modulate prote...; 关键词：Targeted protein degradation Membrane and extracellular proteins Transferrin receptor-targeting chimeras Protein homeostasis regulation Tumor therapy

Donor-specific antibodies against HLA-C,HLA-DP and HLA-DQ and their implications in kidney transplantation: 《World Journal of Transplantation》2025年第2期30-48,共19页Muhammad Abdul Mabood Khalil Nihal Mohammed Sadagah Ishida Hediki Jackson Tan Salem H Al-Qurashi; HLA-C,HLA-DP and HLA-DQ are thought to be benign due to low expression and few initial negative studies.Historically,most allocation programs used HLA-A,HLA-B and HLA-DR antigens for matching.With the advent and use o...; 关键词：Kidney transplantation HLA-C HLA-DP HLA-DQ Donor specific antibodies Review

Approved delivery strategies for biopharmaceuticals: 《Chinese Chemical Letters》2025年第2期41-51,共11页Makhloufi Zoulikha Zhongjian Chen Jun Wu Wei He; supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.21KJA320003);the Scientific Research Project of Jiangsu Commission of Health(No.LKZ2023001)。; In recent years,biopharmaceuticals have witnessed remarkable advancements,transforming the landscape of therapeutic interventions.Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnolo...; 关键词：BIOPHARMACEUTICALS Nucleic acids Monoclonal antibodies PROTEINS Drug delivery

Research landmarks on the 60th anniversary of Epstein-Barr virus: 《Science China(Life Sciences)》2025年第2期354-380,共27页Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng; supported by the National Key Research and Development Program of China(2022YFC3400900);the National Natural Science Foundation of China(82030046,82402614);the Postdoctoral Fellowship Program of CPSF(GZB20230886);the Chinese Postdoctoral Science Foundation(2023M743998,2024T171080);Fundamental Research Funds for the Central Universities(24qnpy278);Shenzhen Medical Research Fund(A2302028)。; Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases...; 关键词：EPSTEIN-BARR virus oncovirus IMMUNE response EPIDEMIOLOGY vaccines ANTIBODIES

Sero-Prevalence of Peste des Petits Ruminants Virus Antibodies in Sudanese Sheep and Goats before and after Vaccination: 《Journal of Biosciences and Medicines》2025年第1期21-40,共20页Omer Algezoli Selma Kamal Yazeed Raouf Alamin Mozdalifa Hiba Ali Mohamed Aljameel Salih Sir Elkhatim Sulieman Ahmed Ibtesam Fadul Elsied Tageldin Nour Mohamed Abdalla; Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cEL...; 关键词：Peste des Petits Ruminants (PPR) Vaccination Efficacy SEROPREVALENCE Herd Immunity High-Risk Area

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