Research landmarks on the 60th anniversary of Epstein-Barr virus  

作　　者：Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng 

机构地区：[1]State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China [2]Viral Immunobiology,Institute of Experimental Immunology,University of Zürich,Zürich 8092,Switzerland [3]Division of Infectious Diseases,Department of Medicine,Brigham and Women’s Hospital,Boston MA 02115,USA [4]Department of Microbiology,Harvard Medical School,Boston MA 02115,USA [5]Harvard Program in Virology,Boston MA 02115,USA [6]Broad Institute of Harvard and MIT,Cambridge MA 02142,USA

出　　处：《Science China(Life Sciences)》2025年第2期354-380,共27页中国科学(生命科学英文版)

基　　金：supported by the National Key Research and Development Program of China(2022YFC3400900);the National Natural Science Foundation of China(82030046,82402614);the Postdoctoral Fellowship Program of CPSF(GZB20230886);the Chinese Postdoctoral Science Foundation(2023M743998,2024T171080);Fundamental Research Funds for the Central Universities(24qnpy278);Shenzhen Medical Research Fund(A2302028)。

摘　　要：Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases.As we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex virus.In this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关 键 词：EPSTEIN-BARR virus oncovirus IMMUNE response EPIDEMIOLOGY vaccines ANTIBODIES 

分 类 号：R73[医药卫生—肿瘤]