Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic  

作　　者：Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M F Antunes Mônica C Carneiro Fabio S Ronzei Julia C Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves 

机构地区：[1]Laboratory of Molecular Epidemiology and Biotechnology,Rodolpho Albino University Laboratory,Fluminense Federal University,Niterói 24241000,Rio de Janeiro,Brazil [2]Estácio de SáUniversity,Nova Friburgo 28611135,Rio de Janeiro,Brazil [3]Pathology Program,Medicine school,Fluminense Federal University,Niterói 24070090,Rio de Janeiro,Brazil [4]Department of Pharmaceutical Sciences,Lloyd L.Gregory School of Pharmacy,Palm Beach Atlantic University,West Palm Beach,FL 33401,United States [5]Health Institute of Nova Friburgo,Fluminense Federal University,Nova Friburgo 28613001,Rio de Janeiro,Brazil [6]Department of Epidemiology and Biostatistics,Institute of Collective Health(ISC),Fluminense Federal University,Niterói 24033900,Rio de Janeiro,Brazil [7]Institute of Physical Education,Fluminense Federal University,Niterói 24020005,Rio de Janeiro,Brazil [8]Department of Statistics,Fluminense Federal University,Niterói 24210200,Rio de Janeiro,Brazil [9]Department of Physiology and Pharmacology,Fluminense Federal University,Niterói 24210130,Rio de Janeiro,Brazil

出　　处：《World Journal of Virology》2025年第1期99-107,共9页世界病毒学杂志（英文）

摘　　要：BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory issues.This virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary lifestyle.Serological tests conducted early on have helped identify how the virus is transmitted and how to curb its spread.The study hypothesis was that the rapid serological test for SARS-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university population.AIM To conduct active surveillance for serological expression of anti-SARS-CoV-2 antibodies in individuals within a university setting during the COVID-19 pandemic.METHODS This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July 2021.The study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to participate.Data were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against SARS-CoV-2.Theχ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate associations.RESULTS A total of 1648 individuals were enrolled in the study.The proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%CI:1.02-1.31](P<0.0024),individuals who had been in contact with a COVID-19-positive case(OR=3.49,95%CI:2.34-5.37)(P<0.001),those who had received the COVID-19 vaccine(OR=2.33,95%CI:1.61-3.35)(P<0.001)and social isolation(OR=0.59,95%CI:0.41-0.84)(P<0.004).The likelihood of showing a positive result increased by 16%with ev

关 键 词：Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19 

分 类 号：G645.5[文化科学—高等教育学] R-4[文化科学—教育学]