Progress in regulating inflammatory biomaterials for intervertebral disc regeneration  

作　　者：Honglin Xiang Weikang Zhao Ke Jiang Jiangtao He Lu Chen Wenguo Cui Yuling Li 

机构地区：[1]Department of Orthopaedics,Laboratory of Biological Tissue Engineering and Digital Medicine,Affiliated Hospital of North Sichuan Medical College,No.1 The South of Maoyuan Road,Nanchong,Sichuan,637000,PR China [2]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,197 Ruijin 2nd Road,Shanghai,200025,PR China [3]Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Orthopedic Laboratory of Chongqing Medical University,No.1 Youyi Road,Yuzhong District,Chongqing,400016,PR China

出　　处：《Bioactive Materials》2024年第3期506-531,共26页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(82102578,82102571);Special Project for the Central Government to Guide the Development of Local Science and Technology in Sichuan Province(23ZYZYTS0235);China Postdoctoral Science Foundation(2022M720603,2022M710564);Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX0104,CSTB2022NSCQ-MSX0089);Research Project of Health Commission of Sichuan Province(2023-1601);Research Project of Nanchong Science and Technology Bureau(22SXJCQN0004);Research Project of the Affiliated Hospital of North Sichuan Medical College(2022JB008,2023ZD002).

摘　　要：Intervertebral disc degeneration(IVDD)is rising worldwide and leading to significant health issues and financial strain for patients.Traditional treatments for IVDD can alleviate pain but do not reverse disease progression,and surgical removal of the damaged disc may be required for advanced disease.The inflammatory microenvironment is a key driver in the development of disc degeneration.Suitable anti-inflammatory substances are critical for controlling inflammation in IVDD.Several treatment options,including glucocorticoids,non-steroidal anti-inflammatory drugs,and biotherapy,are being studied for their potential to reduce inflammation.However,anti-inflammatories often have a short half-life when applied directly and are quickly excreted,thus limiting their therapeutic effects.Biomaterial-based platforms are being explored as anti-inflammation therapeutic strategies for IVDD treatment.This review introduces the pathophysiology of IVDD and discusses anti-inflammatory therapeutics and the components of these unique biomaterial platforms as comprehensive treatment systems.We discuss the strengths,shortcomings,and development prospects for various biomaterials platforms used to modulate the inflammatory microenvironment,thus providing guidance for future breakthroughs in IVDD treatment.

关 键 词：Intervertebral disc ANTI-INFLAMMATION BIOMATERIALS Tissue regeneration 

分 类 号：R681.5[医药卫生—骨科学]