DEMETHYLZEYLASTERAL

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相关领域：医药卫生更多>>
相关作者：贺卫国张玉杰更多>>
相关机构：北京美迪克斯生物技术有限公司北京中医药大学赣南医学院更多>>
相关期刊：《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金更多>>
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Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22
《Acta Pharmaceutica Sinica B》2024年第10期4312-4328,共17页Yanyan Zhang Yun Huang Dianping Yu Mengting Xu Hongmei Hu Qing Zhang Minchen Cai Xiangxin Geng Hongwei Zhang Jianhua Xia Mengmeng Guo Dong Lu Hanchi Xu Linyang Li Xing Zhang Qun Wang Sanhong Liu Weidong Zhang 
funded by the National Key Research and Development Program of China(2022YFC3502000);National Natural Science Foundation of China(Nos.82141203,82374086,and 82104459);Shanghai Municipal Science and Technology Major Project(ZD2021CY001,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004,China);Science and Technology Commission of Shanghai Municipality(20YF1458700,China);Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02,China)。
Programmed cell death ligand-1(PD-L1)is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1(PD-1)to promote immune escape of tumor cells.Compared with antibody therapies,small mo...
关键词：DEMETHYLZEYLASTERAL PD-L1 USP22 DEUBIQUITINATION Tumor-infiltrating lymphocytes Colorectal cancer Immune checkpoint blockade Antitumor immunity 
Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer
《Acta Pharmaceutica Sinica B》2022年第5期2619-2622,共4页Jie Chang Ruirui Yang Lifan Chen Zisheng Fan Jingyi Zhou Hao Guo Yinghui Zhang Yadan Liu Guizhen Zhou Keke Zhang Kaixian Chen Hualiang Jiang Mingyue Zheng Sulin Zhang 
supported by the National Natural Science Foundation of China (81903639 to Sulin Zhang,China);Lingang Laboratory (LG202102-01-02 to Mingyue Zheng,China,LG-QS-202204-01 to Sulin Zhang,China);Shanghai Municipal Science and Technology Major Project (Hualiang Jiang,China);Shanghai Sailing Program (19YF1457800 to Sulin Zhang,China)。
To the Editor:ADP-ribosylation factor 1 (ARF1) plays a critical role in regulating vesicle formation and transport1. The dysregulation of ARF1 expression and/or activity is involved in many human cancers, such as brea...
关键词：ADP-ribosylation factor 1 Breast cancer DEMETHYLZEYLASTERAL Virtual screening 
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