PYRAZINAMIDE

作品数：14被引量：39H指数：3
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相关领域：医药卫生更多>>
相关机构：中国科学院大学更多>>
相关期刊：《Journal of Rare Earths》《Journal of Tuberculosis Research》《World Journal of Gastroenterology》《Journal of US-China Medical Science》更多>>
相关基金：国家自然科学基金更多>>
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Understanding antituberculosis drug-induced hepatotoxicity:Risk factors and effective management strategies in the pediatric population
《World Journal of Clinical Pediatrics》2025年第2期47-55,共9页Pooja Semwal Manjit Kaur Saini Moinak Sen Sarma 
Antituberculosis drug-induced hepatotoxicity(ATDIH)is a significant concern while managing pediatric tuberculosis.There is limited data on pediatric ATDIH,and much of the management practices are extrapolated from adu...
关键词：Antituberculosis therapy DRUG Liver INJURY Isonaizid RIFAMPICIN PYRAZINAMIDE 
Anti-Tuberculosis Drug Induced Liver Injury and Ursodeoxycholic Acid
《Journal of Tuberculosis Research》2020年第2期66-72,共7页Susanne M. Lang Emad Al-Nemnem Helmut Schiffl 
Hepatotoxicity induced by standard anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide) can result in significant morbidity and, rarely, even mortality. This major adverse side-effect of anti-tuberculosis tre...
关键词：Ursodeoxycholic Acid HEPATOTOXICITY RIFAMPICIN ISONIAZID PYRAZINAMIDE TUBERCULOSIS 
Calcitriol enhances pyrazinamide treatment of murine tuberculosis
《Chinese Medical Journal》2019年第17期2089-2095,共7页Jing Zhang Ming Guo Zhi-Xiang Huang Rong Bao Qian Yu Ming Dai Xin Wang Yan Rao 
Background: Tuberculosis is a leading cause of morbidity and mortality in humans worldwide. There is an urgent need for new and effective drugs to treat tuberculosis and shorten the duration of tuberculosis therapy. 1...
关键词：MYCOBACTERIUM TUBERCULOSIS CALCITRIOL PYRAZINAMIDE VITAMIN D 
Clinical and experimental research in antituberculosis drug-induced hepatotoxicity:a review被引量：23
《Journal of Integrative Medicine》2017年第1期27-36,共10页Udhaya Lavinya Baskaran Evan Prince Sabina 
Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs （ATDs）. There are several risk factors associated with the development of hepatotoxicity in such patients. Tho...
关键词：antitubercular agents ISONIAZID RIFAMPICIN PYRAZINAMIDE oxidative stress complementarytherapies 
High Resolution Melting Curve Analysis for Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis Clinical Isolates
《Journal of Tuberculosis Research》2016年第4期155-172,共18页Fatima Osman Farzana Ismail Ayman Osman Shaheed Omar Halima Said Nazir Ismail 
Background: Pyrazinamide (PZA) is one of the most important drugs for tuberculosis (TB) treatment, however, its susceptibility is not routinely tested. High-resolution melting (HRM) curve analysis has been widely used...
关键词：PYRAZINAMIDE TUBERCULOSIS High Resolution Melting Curve Analysis Drug Resistance pncA Gene 
The Influence of Pyrazinamide Monoresistance on Treatment Outcomes in Tuberculosis Patients from Southern China被引量：2
《Journal of Tuberculosis Research》2016年第1期9-17,共9页Shouyong Tan Yunwei Rao Jintao Guo Yaoju Tan Xingshan Cai Haobin Kuang Yanqiong Li Wenyan Liu Julius Mugweru Bangxing Wang Yuanyuan Cao Changwei Wang Ying Zhang Tianyu Zhang 
This study aimed to explore the influence of pyrazinamide (PZA) monoresistance on the treatment outcome of otherwise drug susceptible tuberculosis (TB). A cohort of 194 TB patients that were infected with strains susc...
关键词：TUBERCULOSIS PYRAZINAMIDE TREATMENT Monoresistance 
Effects on type 2 diabetes complicated with pulmonary tuberculosis:regiment of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol versus the regiment plus Qi-boosting and Yin-nourishing decoction of Traditional Chinese Medicine被引量：4
《Journal of Traditional Chinese Medicine》2015年第3期260-265,共6页Shi Guangcan Zhang Ligong 
OBjECTIVE:To observe the clinical effect on type 2diabetes mellitus(T2DM) complicated with pulmonary tuberculosis(TB) of insulin,isoniazid,rifampicin,pyrazinamide and ethambutol(conventional medication) administered t...
关键词：Diabetes mellitus type 2 Tuberculosis pulmonary Qi and Yin deficiency Medicine Chinese traditional 
Anti-hepatotoxic and antioxidant influence of Ipomoea carnea against anti-tubercular drugs induced acute hepatopathy in experimental rodents被引量：1
《Journal of Coastal Life Medicine》2013年第4期293-299,共7页Ramesh Kumar Gupta Ashok Kumar Gupta Sudhansu Ranjan Swain Vaishali Gaurav Gupta Saifuddin Khalid Didagi Kulkarni Suresh Rajnish Kumar Singh 
Supported by Luqman College of Pharmacy,Gulbarga,Karnataka,(Grant No-LCP/GC/09).
Objective:To assess the hepatoprotective effct of Ipomoea carnea(I.carrnea)extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:I.carnea extracts(125,250 and 500 mg/kg,p.o.body we...
关键词：Ipomoea carnea Hepatoprotective ANTIOXIDANT RIFAMPICIN ISONIAZID PYRAZINAMIDE 
Performance of the microscopic observation drug susceptibility assay in pyrazinamide susceptibility testing for Mycobacterium tuberculosis被引量：2
《Chinese Medical Journal》2013年第22期4334-4339,共6页HUANG Zi-kun LUO Qing JIANG Bi-xia LI Wei-ting XU Xiao-meng XIONG Guo-liang and LI Jun-ming 
This study was supported by grants from the National Natural Science Foundation of China （No. 81060001 ） and the Foundation of Scientific ＆ Technical Research Project of Jiangxi Province （No. 2009BSB11219）.
Background Drug susceptibility assay is very important in tuberculosis therapy. Pyrazinamide is a first line antituberculosis drug and diagnosis of its resistance in Mycobacterium tuberculosis （M. tuberculosis） is d...
关键词：microscopic observation drug susceptibility Mycobacterium tuberculosis susceptibility test PYRAZINAMIDE 
Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents被引量：2
《Asian Pacific Journal of Tropical Biomedicine》2012年第6期454-460,共7页Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao 
financially supported by Department of Science&Technology,Government of India,New Delhi(Grant no.GAP-274625)
Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract of...
关键词：SOLANUM xanthocarpum Rifampicin ISONIAZID PYRAZINAMIDE Antioxidant Antihepatotoxicity Hepatoprotective effect ANTITUBERCULAR drug LIVER toxicity LIVER injury Biochemical parameter Histopathology 
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