Sirt5 desuccinylates Cdc42 to mediate osteoclastogenesis and bone remodeling in mice  

作　　者：Yuang Zhanngg Jing Wang Jing Luan Chuanju Liu Yazhou Cui Jinxiang Han 

机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Ji'nan,Shandong 250014,China [2]Biomedical Sciences College&Shandong Medicinal Biotechnology Centre,Shandong First Medical University&Shandong Academy of Medical Sciences,Ji'nan,Shandong 250117,China [3]NHC Key Laboratory of Biotechnology Drugs(Shandong Academy of Medical Sciences),Ji'nan,Shandong 250117,China [4]Key Lab for Rare&Uncommon Diseases of Shandong Province,Ji'nan,Shandong250117,China [5]Department of Orthopaedic Surgery,New York University Grossman School of Medicine,New York,NY 10003,USA [6]Department of Cell Biology,New York University Grossman School of Medicine,NewYork,NY10016,USA

出　　处：《Genes & Diseases》2024年第3期75-78,共4页基因与疾病（英文）

基　　金：supported by the Academic Promotion Programme of Shandong First Medical University(China)(No.2019LJ001);the National Natural Science Foundation of China(No.81772300,82101903);The Innovation Project of Shandong Academy of Medical Sciences,Shandong,China。

摘　　要：Post-translational modifications(PTMs)play a critical role in bone remodeling,with phosphorylation and acetylation being particularly well characterized.Recently,succinylation,a relatively uncommon PTM on lysine,has received considerable research attention for its influence on several physiological and pathological processes and conditions.1 Several substrates involved in mitochondrial pathways have been validated as substrates for the desuccinylase sirtuin 5(Sirt5),a key regulator of succinylation.2 Bone is one of the most metabolically active organs,but the role of succinylation during bone remodeling is not well characterized.

关 键 词：REMODELING ORGANS media 

分 类 号：R68[医药卫生—骨科学]