Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality  

作　　者：Qianqian Guo Hai Qin Zelong Chen Wenzhou Zhang Lufeng Zheng Tingting Qin 

机构地区：[1]Department of Pharmacy,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou,Henan 450008,China [2]Department of Clinical Laboratory,Beijing Jishuitan Hospital Guizhou Hospital,Guiyang,Guizhou 550014,China [3]The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Artificial Intelligence and IoT Smart Medical Engineering Research Center of Henan Province,Zhengzhou,Henan 450008,China [4]School of Life Science and Technology,Jiangsu Key Laboratory of Carcinogenesis and Intervention,China Pharmaceutical University,Nanjing,Jiangsu 211198,China

出　　处：《Genes & Diseases》2025年第3期219-252,共34页基因与疾病(英文)

基　　金：supported by grants from The National Nature Science Foundation of China(No.82173842);WU JIEPING Medical Foundation(No.320.6750.2023-05-7);The Medical Science and Technology Research Project of Henan Province,China(No.SBGJ202003010).

摘　　要：The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucialrole in the precise orchestration of diverse cellular protein processes. From steering cellularsignaling pathways and orchestrating cell cycle progression to guiding receptor traffickingand modulating immune responses, this process plays a crucial role in regulating various biological functions. The dysregulation of Ub-mediated signaling pathways in prevalent cancersushers in a spectrum of clinical outcomes ranging from tumorigenesis and metastasis to recurrence and drug resistance. Ubiquitination, a linchpin process mediated by Ub, assumes a central mantle in molding cellular signaling dynamics. It navigates transitions in biological cuesand ultimately shapes the destiny of proteins. Recent years have witnessed an upsurge inthe momentum surrounding the development of protein-based therapeutics aimed at targetingthe Ub system under the sway of cancer stem cells. The article provides a comprehensive overview of the ongoing in-depth discussions regarding the regulation of the Ub system and itsimpact on the development of cancer stem cells. Amidst the tapestry of insights, the articledelves into the expansive roles of E3 Ub ligases, deubiquitinases, and transcription factors entwined with cancer stem cells. Furthermore, the spotlight turns to the interplay with pivotalsignaling pathways the Notch, Hedgehog, Wnt/b-catenin, and Hippo-YAP signaling pathways allplay crucial roles in the regulation of cancer stem cells followed by the specific modulation ofUb-proteasome.

关 键 词：Cancer progression Cancer stem cell E3 ubiquitin ligase Signalingtransduction UBIQUITIN 

分 类 号：R730.2[医药卫生—肿瘤]