Role of autophagy in rejection after solid organ transplantation:A systematic review of the literature  

作　　者：Shu-Min Jiang Xue-Jiao Li Zi-Lin Wang Zhi-Wei Chen Zhi-Long Liu Qiang Li Xiao-Long Chen 

机构地区：[1]Department of Hepatobiliary Surgery,The First Affiliated Hospital of Jinan University,Guangzhou 510630,Guangdong Province,China [2]Guangdong Key Laboratory of Liver Disease Research,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630,Guangdong Province,China

出　　处：《World Journal of Transplantation》2025年第3期79-90,共12页世界移植杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82100691;China Postdoctoral Science Foundation,No.2021M693631.

摘　　要：Organ transplantation has long been recognized as an effective treatment for endstage organ failure,metabolic diseases,and malignant tumors.However,graft rejection caused by major histocompatibility complex mismatch remains a significant challenge.While modern immunosuppressants have made significant strides in reducing the incidence and risk of rejection,they have not been able to eliminate it completely.The intricate mechanisms underlying transplant rejection have been the subject of intense investigation by transplant immunologists.Among these factors,autophagy has emerged as a key player.Autophagy is an evolutionarily conserved mechanism in eukaryotic cells that mediates autophagocytosis and cellular protection.This process is regulated by autophagy-related genes and their encoded protein families,which maintain the material and energetic balance within cells.Additionally,autophagy has been reported to play crucial roles in the development,maturation,differentiation,and responses of immune cells.In the complex immune environment following transplantation,the role and mechanisms of autophagy are gradually being revealed.In this review,we aim to explore the current understanding of the role of autophagy in solid organ rejection after transplantation.Furthermore,we delve into the therapeutic advancements achieved by targeting autophagy involved in the rejection process.

关 键 词：AUTOPHAGY Organ transplantation Graft rejection IMMUNITY Immune modulation 

分 类 号：R617[医药卫生—外科学]