A novel research model of clonal evolution in mantle cell lymphoma at the single-cell genomic level  

作　　者：Li Zhang Yongsheng Liu Liang Wang Li Wang Li Zheng Wei He Li Yan Lvsu Ye Huidan Zhang Junling Tang 

机构地区：[1]Department of Occupational Disease and Poisoning Medicine,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing 400060,China [2]Laboratory of Toxicology,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing 400060,China [3]Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing 400060,China [4]Chongqing Medical and Pharmaceutical College,Chongqing 401331,China [5]School of Engineering and Applied Sciences,Harvard University,Cambridge,MA 02138,USA [6]Department of Hematology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China

出　　处：《Genes & Diseases》2025年第3期35-38,共4页基因与疾病(英文)

基　　金：funded by the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau,China)(No.2023GGXM006,2024ZDXM026,2024MSXM115);the Key Research Project from Science and Technology Department of Sichuan Province,China(No.2019YFS0301);the Chongqing Key Municipal Public Health Specialty Construction Project(China);the Key Research Project from Chongqing Medical and Pharmaceutical Vocational Education Group(China)(No.CQZJ202329);the Incubation Project of the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(China)(No.2022-2023ZD04,2022-2023ZD03,2022-2023MS04,2022-2023MS03,2022-2023MS010);the Science and Technology Research Program of Chongqing Education Commission(China)(No.KJQN202302811).

摘　　要：Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence accounts for 3%e10%of adult non-Hodgkin lymphoma cases.The evolutionary dynamics of MCL clones at the single-cell level remain largely unclear.Our research suggests that MCL may arise from multiple cells within the abnormal microenvironment of the entire hematopoietic lineage,particularly from initiating cells.These initiating cells predominantly consist of CD19^(-)/IgM^(-) subclones and exhibit a disrupted malignant clonal differentiation of pre-B cells along the tumor immunity evolution tree.

关 键 词：hematopoietic lineage mantle cell lymphoma mcl clonal evolution genomic instability tumor immunity evolution tree single cell genomic level genetic heterogeneity mantle cell lymphoma 

分 类 号：R733.1[医药卫生—肿瘤]