Interest of Non-Invasive Methods to Predict Esophageal Varices in Cirrhotic Patients in Togo  

作　　者：Laté Mawuli Lawson-Ananissoh Mawunyo Henoc Gbolou Yendoukoa Yves Kanake Diane Laure Moumeni Lidawu Roland-Moïse Kogoe Debehoma Venceslas Redah Aklesso Bagny Laté Mawuli Lawson-Ananissoh;Mawunyo Henoc Gbolou;Yendoukoa Yves Kanake;Diane Laure Moumeni;Lidawu Roland-Moïse Kogoe;Debehoma Venceslas Redah;Aklesso Bagny(Department of Gastroenterology, University of Lome, Lome, Togo;Department of Hepato-Gastroenterology, Campus Teaching Hospital of Lome, Lome, Togo)

机构地区：[1]Department of Gastroenterology, University of Lome, Lome, Togo [2]Department of Hepato-Gastroenterology, Campus Teaching Hospital of Lome, Lome, Togo

出　　处：《Open Journal of Gastroenterology》2024年第12期439-446,共8页肠胃病学期刊(英文)

摘　　要：Background: upper digestive endoscopy is the best method for detecting esophageal varices, but its invasiveness and cost make it inaccessible to certain social classes. Aim: to evaluate the performance of non-invasive methods for the presumptive diagnosis of esophageal varices in cirrhotic patients in Togo. Patients and method: this was a cross-sectional descriptive and analytical retrospective data collection conducted over 2 years. It included medical records of cirrhotic patients hospitalized in the Hepato-gastroenterology who undergone transaminase assay, blood count, abdominal ultrasound and an upper GI endoscopy. Results: A total of 114 patients were included, 84 of them were men (sex ratio: 2.8). The mean age of patients was 48±14 years. The most frequent reason for admission was abdominal distension (86%). According to the Child-Pugh classification, cirrhosis was decompensated in 109 patients (95.6%). Esophageal varices were present in 71.1% of patients. At a cutoff value of 110 mm for spleen diameter, the sensitivity for prediction of esophageal esophageal varices was 70.4%, with an area under the ROC curve of 0.63. The areas under the ROC curve for prediction of esophageal varices were 0.27;0.29;0.29 respectively for platelet count, platelet/spleen diameter ratio and the [platelets²/spleen diameter] x AST level. A low [platelets²/spleen diameter] x AST level ratio correlated with the presence of esophageal varices at endoscopy. Conclusion: Spleen diameter is a performant non-invasive tool for the prediction of esophageal varices.Background: upper digestive endoscopy is the best method for detecting esophageal varices, but its invasiveness and cost make it inaccessible to certain social classes. Aim: to evaluate the performance of non-invasive methods for the presumptive diagnosis of esophageal varices in cirrhotic patients in Togo. Patients and method: this was a cross-sectional descriptive and analytical retrospective data collection conducted over 2 years. It included medical records of cirrhotic patients hospitalized in the Hepato-gastroenterology who undergone transaminase assay, blood count, abdominal ultrasound and an upper GI endoscopy. Results: A total of 114 patients were included, 84 of them were men (sex ratio: 2.8). The mean age of patients was 48±14 years. The most frequent reason for admission was abdominal distension (86%). According to the Child-Pugh classification, cirrhosis was decompensated in 109 patients (95.6%). Esophageal varices were present in 71.1% of patients. At a cutoff value of 110 mm for spleen diameter, the sensitivity for prediction of esophageal esophageal varices was 70.4%, with an area under the ROC curve of 0.63. The areas under the ROC curve for prediction of esophageal varices were 0.27;0.29;0.29 respectively for platelet count, platelet/spleen diameter ratio and the [platelets²/spleen diameter] x AST level. A low [platelets²/spleen diameter] x AST level ratio correlated with the presence of esophageal varices at endoscopy. Conclusion: Spleen diameter is a performant non-invasive tool for the prediction of esophageal varices.

关 键 词：Esophageal Varices SPLEEN PLATELETS TOGO 

分 类 号：R57[医药卫生—消化系统]