LYMPHANGIOGENESIS

作品数：83被引量：328H指数：11
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相关领域：医药卫生生物学更多>>
相关作者：朱波王艳陈正堂杨新明唐青来更多>>
相关机构：第三军医大学新桥医院中南大学上海交通大学医学院附属瑞金医院华中科技大学更多>>
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Platelet activation relieves liver portal hypertension via the lymphatic system though the classical vascular endothelial growth factor receptor 3 signaling pathway
《World Journal of Gastroenterology》2025年第10期86-102,共17页Min Chen Jin-Bo Zhao Guang-Bo Wu Zheng-Hao Wu Gu-Qing Luo Zhi-Feng Zhao Chi-Hao Zhang Jia-Yun Lin Hong-Jie Li Xiao-Liang Qi Hai-Zhong Huo Abudukadier Tuersun Qiang Fan Lei Zheng Meng Luo 
Supported by the National Natural Science Foundation of China,No.82100639,No.82200630,and No.81970526;Postdoctoral Scientific Research Foundation of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.202401023;Clinical Research Program of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.JYLJ202124;Shanghai Municipal Commission of Health and Family Planning,No.20244Y0195 and No.20234Y0132;the Fundamental Research Program Funding of Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,No.JYZZ162;Science Foundation of Xinjiang Uygur Natural Autonomous Region,No.2022D01F17.
BACKGROUND Liver cirrhosis and portal hypertension(PHT)can lead to lymphatic abnormalities and coagulation dysfunction.Because lymphangiogenesis may relieve liver cirrhosis and PHT,the present study investigated the g...
关键词：Portal hypertension CIRRHOSIS LYMPHANGIOGENESIS PLATELETS Vascular endothelial growth factor C 
Exosomal miR-224-3p promotes lymphangiogenesis and lymph node metastasis by targeting GSK3B in gastric cancer
《Oncology Research》2025年第2期327-345,共19页ZHENGYANG ZHOU LEI QIAO TONGTONG WANG WEN PAN JINGJING DUAN HAIYANG ZHANG TING DENG YI BA YI HE 
supported by grants from the National Natural Science Foundation of China(Nos.82072664,81974374,82173125,82103677).
Background:Patients with gastric cancer(GC)are prone to lymph node metastasis(LNM),which is an important factor for recurrence and poor prognosis of GC.Nowadays,more and more studies have confirmed that exosomes can p...
关键词：Gastric cancer(GC) Extracellular vesicles(EVs) miR-224-3p Lymph node metastasis(LNM) GSK3B 
DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma
《Chinese Medical Journal》2025年第3期361-363,共3页Baibin Wang Yuan Zhuang Chongrong Weng Yanhui Jiang Bingfan Xie Lijie Wang Yingying Dong Xiangpei Fang Jianzhong He Xiaojin Wang Huanhuan He Yong Chen Huilong Nie 
National Natural Science Foundation of China(Nos.92159105 and 81872113);Guangdong Province(No.2020A0505100028)
To the Editor:Cervical cancer(CC)is the second leading cause of cancer death in women,representing a major global health challenge.[1]Cervical squamous cell carcinoma(CSCC)accounts for 70%of CC cases,and pelvic lymph ...
关键词：pelvic lymph node metastasis squamous cell carcinoma cscc accounts ddx cervical squamous cell carcinoma agrn LYMPHANGIOGENESIS underlying mechanisms lymph node metastasis 
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation
《Signal Transduction and Targeted Therapy》2024年第12期5737-5751,共15页Yingnan Bai Liming Chen Fanghao Guo Jinghong Zhang Jinlin Hu Xuefei Tao Qing Lu Wenyi Li Xueying Chen Ting Gong Nan Qiu Yawei Jin Lifan Yang Yu Lei Chengchao Ruan Qing Jing John PCooke Shijun Wang Yunzeng Zou Junbo Ge 
supported by National Natural Science Foundation of China grants 81900434(Dr.Bai Y.),82230009 and 82430016(Dr.Zou Y.),82170255(Dr.Wang S.),82200541(Dr.Guo F.);Program by Shanghai Municipality in 2021(21PJD013);Shanghai Natural Science grant(24ZR1409800);the Fudan University(IDF152064/016);by grants to JPC from the National Institutes of Health(R0-1 HL148338 and HL133254).
EphrinB2(erythropoietin-producing hepatoma interactor B2)is a key Eph/ephrin family member,promoting angiogenesis,vasculogenesis,and lymphangiogenesis during embryonic development.However,the role of EphrinB2 in cardi...
关键词：EPHRINB2 CARDIAC INFLAMMATION 
Long non-coding RNA BANCR promotes pancreatic cancer lymphangiogenesis and lymphatic metastasis by regulating the HIF-1α/VEGF-C/VEGFR-3 pathway via miR-143-5p
《Genes & Diseases》2024年第4期57-60,共4页Shaolong Hao Yu Ji Weixuan Pan Hao Sun Fang Nie Jonathan Ray Warren Yuchuan Ding Wei Han 
supported by the Capital Health Development Scientific Research Project(China)(No.2022-2-7081);Beijing Natural Science Foundation(China)(No.7234377);Science and Technology Plan Project of Tongzhou District,Beijing,China(No.KJ2022CX016).
Pancreatic cancer is one of the most aggressive malignant tumors of the digestive system.Lymph node metastasis(LNM),as the main way of invasion and metastasis,can occur in the early stage of pancreatic cancer and be c...
关键词：METASTASIS cancer INVASION 
Correction:Anti-lymphangiogenesis for boosting drug accumulation in tumors被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期3141-3142,共2页Chunling Wang Junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01794-4,published online 15 April 2024 After the article was published online,1 the authors noticed one inadvertent mistake in ...
关键词：LUNG BOOSTING repeatedly 
Anti-lymphangiogenesis for boosting drug accumulation in tumors被引量：4
《Signal Transduction and Targeted Therapy》2024年第5期2161-2175,共15页Chunling Wang Junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang 
This work was supported by grants from the National Key Research and Development Program of China(2022YFA1206800,2021YFA1201103);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB36000000,G.N.);the National Natural Science Foundation of China(32371520);the Beijing Natural Science Foundation(Z210017);the Key Research Program of Frontier Sciences CAS(ZDBS-LY-SLH039),the Youth Innovation Promotion Association CAS(2022166);the Fundamental Research Funds for the Central Universities.The authors thank Han Ouyang(School of Nanoscience and Engineering,University of Chinese Academy of Sciences)for the help of intratumoral interstitial fluid pressure(IFP)assay.
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines.Various strategies a...
关键词：DRUGS ANGIOGENESIS METASTASIS 
NAT10-mediated ac 4 C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1被引量：1
《Cancer Communications》2024年第3期361-383,共23页Daojia Miao Jian Shi Qingyang Lv Diaoyi Tan Chuanyi Zhao Zhiyong Xiong Xiaoping Zhang 
This study was supported by the National Natural Sci-ence Foundation of China(81874090,81972630,82202911,82300786).
Background:Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma(ccRCC).N-acetyltransferase 10(NAT10)is known to catalyze N4-acetylcytidine(...
关键词：clear-cell renal cell carcinoma N4-acetylcytidine N-acetyltransferase 10 YAP1 nuclear import 
An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis被引量：1
《Cancer Communications》2023年第12期1289-1311,共23页Yuting Li Hanhao Zheng Yuming Luo Yan Lin Mingjie An Yao Kong Yue Zhao Yina Yin Le Ai Jian Huang Changhao Chen 
funded by the National Key Research and Development Program of China(Grant No.2022YFA1305500 and 2018YFA0902803);the National Natural Science Foundation of China(Grant No.82173272,82173271,81825016,82103536,82103416,81871945 and 81902589);Guangdong Basic and Applied Basic Research Foundation(Grant No.2021B1515020091,2020A1515010815,2018B010109006,and 2021A1515010355);the Science and Technology Program of Guangzhou,China(Grant No.202002030388,201803010049,and 2017B020227007).
Background Cancer-associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor-derived extracellular vesicles (EVs) are the critical...
关键词：bladder cancer Cancer-associated fibroblasts extracellular vesicles HGF LYMPHANGIOGENESIS lymph node metastasis long non-coding RNA positive feedback loop 
Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma
《Genes & Diseases》2023年第6期2226-2228,共3页Meng Sha Chuan Shen Seogsong Jeong Ning Xu Chen Chen Hua-lian Hang Ying Tong Jie Cao 
supported by the National Natural Science Foundation of China(No.81902379);Cultivation Foundation of Renji Hospital,Shanghai,China(No.RJPY-LX-011);National Key Research on Precision Medicine of China(No.2018ZX10723204).
Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little known.Cancerassociat...
关键词：CAFs LYMPHATIC MESENCHYMAL 
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