DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma  

作　　者：Baibin Wang Yuan Zhuang Chongrong Weng Yanhui Jiang Bingfan Xie Lijie Wang Yingying Dong Xiangpei Fang Jianzhong He Xiaojin Wang Huanhuan He Yong Chen Huilong Nie 

机构地区：[1]Guangdong Provincial Engineering Research Center of Molecular Imaging,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China [2]Department of Gynecology,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China [3]The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China [4]Department of Pathology,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China [5]Department of Cardiothoracic Surgery,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,China

出　　处：《Chinese Medical Journal》2025年第3期361-363,共3页中华医学杂志(英文版)

基　　金：National Natural Science Foundation of China(Nos.92159105 and 81872113);Guangdong Province(No.2020A0505100028)

摘　　要：To the Editor:Cervical cancer(CC)is the second leading cause of cancer death in women,representing a major global health challenge.[1]Cervical squamous cell carcinoma(CSCC)accounts for 70%of CC cases,and pelvic lymph node metastasis is a critical cause of CC-related death.[2]Thus,understanding the underlying mechanisms of the tumor spread through lymphatic vessels becomes imperative.[3]RNA helicases are involved in almost all aspects of RNA metabolism.[4]DEAD-box helicase 24(DDX24),one of the least explored DEAD-box RNA helicases,was upregulated in several cancer types.[5]However,the role of DDX24 in CSCC progression and metastasis remains elusive.Here,we investigated the essential role of DDX24 in mediating cancer cell EMT and lymphangiogenesis in the context of CSCC.Our study provides a potential therapeutic target for CSCC lymphatic metastasis.

关 键 词：pelvic lymph node metastasis squamous cell carcinoma cscc accounts ddx cervical squamous cell carcinoma agrn LYMPHANGIOGENESIS underlying mechanisms lymph node metastasis 

分 类 号：R737.33[医药卫生—肿瘤]