Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma  

作　　者：Meng Sha Chuan Shen Seogsong Jeong Ning Xu Chen Chen Hua-lian Hang Ying Tong Jie Cao 

机构地区：[1]Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [2]Department of Biomedical Informatics,CHA University School of Medicine,CHA University,Seongnam 13488,Republic of Korea [3]Institute of Basic Medical Sciences,School of Medicine,CHA University,Seongnam 13488,Republic of Korea [4]Institute for Biomedical Informatics,School of Medicine,CHA University,Seongnam 13488,Republic of Korea

出　　处：《Genes & Diseases》2023年第6期2226-2228,共3页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81902379);Cultivation Foundation of Renji Hospital,Shanghai,China(No.RJPY-LX-011);National Key Research on Precision Medicine of China(No.2018ZX10723204).

摘　　要：Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little known.Cancerassociated fibroblasts(CAFs)enhance tumor progression through many aspects.2 CAFs have been discovered exhibiting cellular plasticity of phenotypic transition-such as epithelial-mesenchymal transition(EMT)which promotes increased migratory and invasive capabilities of cells.3However,mesenchymal-to-endothelial,(MEndT)transition is yet to be identified in tumor entities.

关 键 词：CAFs LYMPHATIC MESENCHYMAL 

分 类 号：R73[医药卫生—肿瘤]