Tug of war:Understanding the dynamic interplay of tumor biomechanical environment on dendritic cell function  

作　　者：Brian Chesney Quartey Gabriella Torres Mei ElGindi Aseel Alatoom Jiranuwat Sapudom Jeremy C.M Teo 

机构地区：[1]Laboratory for Immuno Bioengineering Research and Applications,Division of Engineering,New York University Abu Dhabi,Abu Dhabi,United Arab Emirates [2]Department of Biomedical Engineering,Tandon School of Engineering,New York University,NY,USA [3]Department of Biology,Center for Genomics and Systems Biology,New York University,New York,NY,USA [4]Department of Mechanical Engineering,Tandon School of Engineering,New York University,NY,USA

出　　处：《Mechanobiology in Medicine》2024年第3期7-21,共15页力学生物学与医学（英文）

基　　金：support from New York University Abu Dhabi(NYUAD)Faculty Research.Fund(AD266)。

摘　　要：Dendritic cells(DCs)play a pivotal role in bridging the innate and adaptive immune systems.From their immature state,scavenging tissue for foreign antigens to uptake,then maturation,to their trafficking to lymph nodes for antigen presentation,these cells are exposed to various forms of mechanical forces.Particularly,in the tumor microenvironment,it is widely known that microenvironmental biomechanical cues are heightened.The source of these forces arises from cell-to-extracellular matrix(ECM)and cell-to-cell interactions,as well as being exposed to increased microenvironmental pressures and fluid shear forces typical of tumors.DCs then integrate these forces,influencing their immune functions through mechanotransduction.This aspect of DC biology holds alternative,but important clues to understanding suppressed/altered DC responses in tumors,or allow the artificial enhancement of DCs for therapeutic purposes.This review discusses the current understanding of DC mechanobiology from the perspectives of DCs as sensors of mechanical forces and providers of mechanical forces.

关 键 词：Dendritic cells MECHANOBIOLOGY Biomechanical cues Antigen uptake Antigen presentation Immunotherapy 

分 类 号：R730[医药卫生—肿瘤]