Harnessing mechanobiology to enhance cell therapy  

作　　者：Peixiang Ma An Qin Tobias Winkler Jie Zhao 

机构地区：[1]Department of Orthopaedics,Shanghai Key Laboratory of Orthopaedic Implant,Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China [2]Berlin Institute of Health at Charite–Universit€atsmedizin Berlin,Berlin Institute of Health Center for Regenerative Therapies,Berlin,Germany [3]Charite–Universit€atsmedizin Berlin,Corporate member of Freie Universit€at Berlin and Humboldt-Universit€at zu Berlin,Center for Musculoskeletal Surgery,Berlin,Germany [4]Berlin Institute of Health at Charite–Universit€atsmedizin Berlin,Julius Wolff Institute,Berlin,Germany

出　　处：《Mechanobiology in Medicine》2024年第4期4-6,共3页力学生物学与医学（英文）

基　　金：supported by the National Science Foundation of China(82130073 J.Z.);National Key R&D Program of China(2021YFA1100802 P.M.);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System,Biomaterials and Regenerative Medicine Institute Cooperative,Research Project,Shanghai Jiaotong University School of Medicine(2022LHA01 J.Z.).

摘　　要：Recent developments in cell therapy have revolutionized medical treatment.While various methods of stimulation have been explored,the role of mechanical force has often been overlooked.Although mechanical loading is not easily visible,it can actively reshape organisms,and abnormal mechanical loading can lead to injury and disease.By leveraging the mechanobiology of cells,we can equip them with synthetic mechanosensors that can redirect genetic circuits to express protective factors,such as antibodies and cytokines,according to the mechanical force signal.The advancement of artificial intelligence(AI)presents a fascinating opportunity to redesign more complex mechanoreceptors,allowing cells to respond to intricate stimuli.Additionally,genetic engineering tools like CRISPR-Cas9,base editing,and prime editing enable the creation of multiple gene circuits for cells to react to complex mechanical environments.Advanced mechanical loading techniques,such as focused ultrasound,deliver signals in a confined spatial and temporal manner.Therefore,harnessing mechanobiology in cells can develop more flexible,personalized,and precise cell therapies.

关 键 词：Cell therapy MECHANOBIOLOGY Mechanogenetics Synthetic biology 

分 类 号：R318[医药卫生—生物医学工程]