The motor-clutch model in mechanobiology and mechanomedicine  

作　　者：Zhao Xu Feng Xu Bo Cheng 

机构地区：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology,Xi'an Jiaotong University,Shaanxi,710049,PR China [2]Bioinspired Engineering and Biomechanics Center(BEBC),Xi'an Jiaotong University,Shaanxi,710049,PR China

出　　处：《Mechanobiology in Medicine》2024年第3期22-30,共9页力学生物学与医学（英文）

摘　　要：Cellular behaviors such as migration,spreading,and differentiation arise from the interplay of cell–matrix interactions.The comprehension of this interplay has been advanced by the motor-clutch model,a theoretical framework that captures the binding-unbinding kinetics of mechanosensitive membrane-bound proteins involved in mechanochemical signaling,such as integrins.Since its introduction and subsequent development as a computational tool,the motor clutch model has been instrumental in elucidating the impact of biophysical factors on cellular mechanobiology.This review aims to provide a comprehensive overview of recent advances in the motor-clutch modeling framework,its role in elucidating the relationships between mechanical forces and cellular processes,and its potential applications in mechanomedicine.

关 键 词：MECHANOBIOLOGY Mechanomedicine Molecular-clutch model INTEGRIN Cell migration Cell behavior 

分 类 号：R318[医药卫生—生物医学工程]