Retinoblastoma: The Situation in Burkina Faso over Ten Years  

作　　者：Amadou Ouattara Anicet Corneille Beremwidougou Paté Sankara Mariam Traore Dolo Tierinyê Armand Meda Windinmanégdé Pierre Djiguimde Rolande Kabore Chantal Gabrielle Bouda Gertrude Augustine Meda Hien Jerome Sanou Jean Wenceslas Diallo Ahgbatouhabeba Zabsonre Ahnoux Amadou Ouattara;Anicet Corneille Beremwidougou;Paté Sankara;Mariam Traore Dolo;Tierinyê Armand Meda;Windinmanégdé Pierre Djiguimde;Rolande Kabore;Chantal Gabrielle Bouda;Gertrude Augustine Meda Hien;Jerome Sanou;Jean Wenceslas Diallo;Ahgbatouhabeba Zabsonre Ahnoux(Ophthalmology Department, Regional University Hospital of Ouahigouya, Ouahigouya, Burkina Faso;Regional University Hospital of Ouahigouya, Ouahigouya, Burkina Faso;National Center for the Fight against Blindness, Ouagadougou, Burkina Faso;University Hospital of Sour Sanou, Bobo-Dioulasso, Burkina Faso;Nouna District Hospital, Nouna, Burkina Faso;University Hospital of Bogodogo, Ouagadougou, Burkina Faso;University Hospital of Yalgado Ouedraogo, Ouagadougou, Burkina Faso)

机构地区：[1]Ophthalmology Department, Regional University Hospital of Ouahigouya, Ouahigouya, Burkina Faso [2]Regional University Hospital of Ouahigouya, Ouahigouya, Burkina Faso [3]National Center for the Fight against Blindness, Ouagadougou, Burkina Faso [4]University Hospital of Sour Sanou, Bobo-Dioulasso, Burkina Faso [5]Nouna District Hospital, Nouna, Burkina Faso [6]University Hospital of Bogodogo, Ouagadougou, Burkina Faso [7]University Hospital of Yalgado Ouedraogo, Ouagadougou, Burkina Faso

出　　处：《Open Journal of Ophthalmology》2024年第3期175-195,共21页眼科学期刊（英文）

摘　　要：Context: In Burkina Faso, there is only one retinoblastoma treatment center located in the capital. Nowadays, the treatment of retinoblastoma has benefited from the contribution of scientific progress. Objective: The aim was to take stock of the situation of retinoblastoma in the pediatric oncology department from January 1, 2010 to December 31, 2019. Materials and Methods: This was a descriptive cross-sectional study with retrospective data collection over a 10-year period, based on records of patients admitted to pediatric oncology department of CHU-YO. Data were analysed using CS Pro version 7.2 software. Categorical variables were compared using Pearsons Chi-square test at the 5% significance level. Overall survival was estimated using the Kaplan-Meier method. Operational definitions were used for lost to follow-up, consultation and diagnosis delays. Results: We collected a total of 204 cases in 10 years, i.e. an annual average of 20.4 cases/year. The mean age at diagnosis was 37.5 months for unilateral cases and 26.4 months for bilateral cases. Male predominance was noted, with a sex ratio of 1.31. The majority of patients came from disadvantaged backgrounds (72% farming fathers and 91% housewives). Clinically, leukocoria and exophthalmos were the main presenting features. The average time to consultation was long (8.73 months) and unilateral localization was predominantly unilateral at 77%. In terms of treatment, 102 patients were eligible for curative treatment and 80 for palliative treatment. The prognosis was poor, with 41% death and numerous cases of lost to follow-up (18%). Overall survival was estimated at 32%. The factor associated with the lethality of retiniblastoma was the extension of the tumor to other organs. Conclusion: Recognition of the early clinical signs of retinoblastoma can anticipate the occurrence of this cancer. Health professionals should be encouraged to perform the Buckner test every time they come into contact with children aged 0 to 5, and the public should be encouraged to examContext: In Burkina Faso, there is only one retinoblastoma treatment center located in the capital. Nowadays, the treatment of retinoblastoma has benefited from the contribution of scientific progress. Objective: The aim was to take stock of the situation of retinoblastoma in the pediatric oncology department from January 1, 2010 to December 31, 2019. Materials and Methods: This was a descriptive cross-sectional study with retrospective data collection over a 10-year period, based on records of patients admitted to pediatric oncology department of CHU-YO. Data were analysed using CS Pro version 7.2 software. Categorical variables were compared using Pearsons Chi-square test at the 5% significance level. Overall survival was estimated using the Kaplan-Meier method. Operational definitions were used for lost to follow-up, consultation and diagnosis delays. Results: We collected a total of 204 cases in 10 years, i.e. an annual average of 20.4 cases/year. The mean age at diagnosis was 37.5 months for unilateral cases and 26.4 months for bilateral cases. Male predominance was noted, with a sex ratio of 1.31. The majority of patients came from disadvantaged backgrounds (72% farming fathers and 91% housewives). Clinically, leukocoria and exophthalmos were the main presenting features. The average time to consultation was long (8.73 months) and unilateral localization was predominantly unilateral at 77%. In terms of treatment, 102 patients were eligible for curative treatment and 80 for palliative treatment. The prognosis was poor, with 41% death and numerous cases of lost to follow-up (18%). Overall survival was estimated at 32%. The factor associated with the lethality of retiniblastoma was the extension of the tumor to other organs. Conclusion: Recognition of the early clinical signs of retinoblastoma can anticipate the occurrence of this cancer. Health professionals should be encouraged to perform the Buckner test every time they come into contact with children aged 0 to 5, and the public should be encouraged to exam

关 键 词：RETINOBLASTOMA PROGNOSIS Pediatric Oncology CHU-YO Burkina Faso 

分 类 号：R73[医药卫生—肿瘤]