TRANSDIFFERENTIATION

作品数：78被引量：430H指数：11
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相关领域：医药卫生更多>>
相关作者：金娟周雅利高博刘建刘少峰更多>>
相关机构：浙江省人民医院第四军医大学西京医院东南大学扬州大学更多>>
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Perspectives on Schwann-like cells derived from bone marrowmesenchymal stem cells:Advancing peripheral nerve injury therapies
《World Journal of Stem Cells》2025年第2期141-146,共6页Lucas Vinícius de Oliveira Ferreira Rogério Martins Amorim 
Peripheral nerve injuries are clinical conditions that often result in functional deficits,compromising patient quality of life.Given the relevance of these injuries,new treatment strategies are constantly being inves...
关键词：Cell therapy Nerve repair Peripheral nervous system TRANSDIFFERENTIATION TRANSPLANTATION 
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
《Acta Pharmacologica Sinica》2024年第11期2290-2299,共10页Zi-yang Chen Si-jia Ji Chen-wen Huang Wan-zhi Tu Xin-yue Ren Ren Guo Xin Xie 
supported by grants from the Ministry of Science and Technology of China(2022YFA1104700 and 2022ZD0204700 to XX);the National Natural Science Foundation of China(82121005 and 82330113 to XX,31900518 to CWH);Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022280 to RG);Fundamental Research Projects of Science&Technology Innovation and Development Plan in Yantai City(2023JCYJ063 to RG);Taishan Scholars Program to XX.
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate.Condition like myocardial infarction causes massive death of cardiomyocytes and is the leading cause of death.Prev...
关键词：cardiac transdifferentiation in situ transdifferentiation small molecules CARDIOMYOCYTES FIBROBLASTS in vivo transdifferentiation 
In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke被引量：1
《Neural Regeneration Research》2024年第10期2240-2248,共9页Meng Yuan Yao Tang Tianwen Huang Lining Ke En Huang 
supported by the National Natural Science Foundation of China,No.82071418;the Natural Science Foundation of Fujian Province,No.2020J01612 (both to EH)。
In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been sho...
关键词：astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 TRANSDIFFERENTIATION 
Neuronal conversion from glia to replenish the lost neurons被引量：1
《Neural Regeneration Research》2024年第7期1446-1453,共8页Shiyu Liang Jing Zhou Xiaolin Yu Shuai Lu Ruitian Liu 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDB39050600(to RL);the National Natural Science Foundation of China,No.81971610(to RL);Beijing Rehabilitation Hospital Introduction of Talent Research Start-up Fund,No.2021R-008(to JZ)。
Neuronal injury,aging,and cerebrovascular and neurodegenerative diseases such as cerebral infarction,Alzheimer’s disease,Parkinson’s disease,frontotemporal dementia,amyotrophic lateral sclerosis,and Huntington’s di...
关键词：ASTROCYTES neural stem cells neurodegenerative diseases neuron polypyrimidine tract binding protein 1 repair REPROGRAMMING small molecule transcription factor TRANSDIFFERENTIATION 
Pancreatic β-cell failure,clinical implications,and therapeutic strategies in type 2 diabetes被引量：2
《Chinese Medical Journal》2024年第7期791-805,共15页Daxin Cui Xingrong Feng Siman Lei Hongmei Zhang Wanxin Hu Shanshan Yang Xiaoqian Yu Zhiguang Su 
National Natural Science Foundation of China(Nos.82270846 and 81770814);Sichuan Science and Technology Program(No.2023JDRC0095);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(No.Z20201010)
Pancreaticβ-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes(T2D).Reserving insulin-producingβ-cells and hence restoring insulin pr...
关键词：Pancreaticβ-cell regeneration Diabetes INSULIN DEDIFFERENTIATION TRANSDIFFERENTIATION Stem cell 
Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation:neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期184-199,共16页Simon McDowall Vaishali Bagda Stuart Hodgetts Frank Mastaglia Dunhui Li 
funded by Bryant Stokes Neurological Research Fund,FightMND Drug Development Grant,and Channel 7 Telethon research grant.
Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that are lost in patients with neurodegenerative disorders.Several research groups have attempted direct reprogramm...
关键词：Neuronal regeneration Astrocyte-neuron reprogramming Astrocyte heterogeneity Therapeutic strategies 
Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives
《Current Medical Science》2024年第1期1-27,共27页Qi PAN Cheng CHEN Yue-jin YANG 
supported by the National Natural Science Foundation of China(No.81573957,No.81874461 and No.82070307).
Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional ce...
关键词：ATHEROSCLEROSIS TRANSDIFFERENTIATION extracellular traps EFFEROCYTOSIS stem cell nanoparticles 
Establishment of a Fah-LSL mouse model to study BEC-to-hepatocyte conversion
《Biophysics Reports》2023年第6期309-324,共16页Xingrui Wang Wenjuan Pu Huan Zhu Mingjun Zhang Bin Zhou 
supported by the National Science Foundation of China(32370783,32100592,82088101,32050087);National Key Research&Development Program of China(2019YFA0110403,2019YFA0802000);Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01);the Pearl River Talent Recruitment Program of Guangdong Province(2017ZT07S347);The National Ten Thousand Talents Program–the Top-Notch Young Talent;the New Cornerstone Science Foundation through the New Cornerstone Investigator Program and the XPLORER PRIZE
The liver consists predominantly of hepatocytes and biliary epithelial cells(BECs),which serve distinct physiological functions.Although hepatocytes primarily replenish their own population during homeostasis and inju...
关键词：Liver regeneration BEC-to-hepatocyte transdifferentiation Fumarylacetoacetate(Fah)gene Transitional liver progenitor cells(TLPC) Lineage tracing 
Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases被引量：1
《Neural Regeneration Research》2023年第5期955-958,共4页Hazel Quek Anthony R.White 
supported by grants from NHMRC (APP1125796);The Col Bambrick Memorial MND Research Grant;The NTI MND Research Grant;the FightMND Foundation;supported by an NHMRC Senior Research Fellowship APP1118452。
Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on ...
关键词：human in vitro microglia models neurodegeneration neuroinflammation patient heterogeneity patient stratification peripheral blood monocyte-derived microglia-like cells therapeutic target TRANSDIFFERENTIATION translational outcomes 
A T follicular helper cell origin for T regulatory type 1 cells被引量：1
《Cellular & Molecular Immunology》2023年第5期489-511,共23页Patricia Solé Jun Yamanouchi Josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos Julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria 
the Canadian Instutes of Health Research(CIHR)(FDN-353029,PJT-479040,PJT-479038,FRN-168480(with JDRF),DT4-179512);Genome Canada(GAPP program),the Praespero Foundation,the Alberta Diabetes Foundation,theISClll and FEDER(PIE14/00027,Pl15/0797);Ministerio de Ciencia e Innovacion of Spain(MCIN;PID2021-125493OB-I00);Generalitat de Catalunya(SGR and CERCA Programmes)and Red Espanola de Supercomputacion(RES,providing CSUC resources).P.Serra was an investigator of the Ramon y Cajal reintegration program and was supported by a JDRF Career Development Award.P.Sole and J.Garnica were supported by predoctoral studentships from FPU(MCIN).
Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express FOxP3.The identit...
关键词：T-regulatory type 1(TR1)cells autoimmunity T follicular helper(TFH)cells TRANSDIFFERENTIATION nanomedicine 
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