云南高校图书馆联盟文献共享服务平台- DEDIFFERENTIATION

DEDIFFERENTIATION: 作品数：58被引量：170H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：崔克明王雅清杨学义罗旭蔡冬元更多>>; 相关机构：四川农业大学北京大学湖南生物机电职业技术学院重庆大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Toripalimab in combination with chemotherapy effectively suppresses local recurrence and metastatic sarcomatoid renal cell carcinoma:A case report: 《World Journal of Clinical Cases》2024年第28期6230-6236,共7页Ming-Zhu Gao Nian-Fei Wang Jin-You Wang Li Ma Yu-Cai Yang; The Health Research Program of Anhui Province,China,No.AHWJ2022b048;The Research Foundation of Anhui Medical University,China,No.2021xkj164;The Clinical Scientific Research Cultivation Project of the Second Affiliated Hospital of Anhui Medical University,China,No.2021LCZD04.; BACKGROUND Sarcomatoid renal cell carcinoma(SRCC)is a rare variant of renal cell carcinoma associated with an unfavorable prognosis.The efficacy of conventional chemo-therapy and targeted therapies are limited,whereas...; 关键词：Renal cell carcinoma Sarcomatoid dedifferentiation Immune checkpoint inhibitor CHEMOTHERAPY Case report

SOX2/DRD2 signaling pathway facilitates astrocytic dedifferentiation in cerebral ischemic mice: 《神经解剖学杂志》2024年第3期277-286,共10页YI Xuyang KANG Enming WANG Yanjin ZHANG Kun LIN Wei WU Shengxi WANG Yazhou; 国家自然科学基金(82221001,82371402);陕西省自然科学基金(2021JZ-34)。; Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and astrocytes.Methods:Immunofluorescence staining and SOX2-GFP mic...; 关键词：cerebral ischemia ASTROCYTE DEDIFFERENTIATION SOX2 dopamine D2 receptor(DRD2) mouse

Transient induction of actin cytoskeletal remodeling associated with dedifferentiation,proliferation,and redifferentiation stimulates cardiac regeneration被引量：1: 《Acta Pharmaceutica Sinica B》2024年第6期2537-2553,共17页Wenbin Fu Qiao Liao Yu Shi Wujian Liu Hongmei Ren Chunmei Xu Chunyu Zeng; supported by the grant to Chunyu Zeng from the National Key R&D Program of China(2022YFA1104500);the National Natural Science Foundation of China(82200307);the grant to Chunyu Zeng from the National Natural Science Foundation of China(81930008).; The formation of new and functional cardiomyocytes requires a 3-step process:dedifferentiation,proliferation,and redifferentiation,but the critical genes required for efficient dedifferentiation,proliferation,and redi...; 关键词：Single cell analysis Actin remodeling Tmsb4x Tmsb10 Dmd Ctnna3 Myocardial infarction Cardiomyocytes proliferation Cardiac regeneration Genetic therapy

YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation: 《Research》2024年第2期401-415,共15页Jiadi Lv Xiaohan Liu Yabo Zhou Feiran Cheng Haoran Chen Shunshun Li Dianheng Wang Li Zhou Zhenfeng Wang Nannan Zhou Jie Chen Bo Huang; supported by National Natural Science Foundation of China grant nos.82388201 to B.H.and 82003145 to J.L.;Haihe Laboratory of Cell Ecosystem Innovation Fund grant no.22HHXBSS00009 to B.H.;National Key Research and Development Program of China grant no.2022YFA1206000;CAMS Innovation Fund for Medical Sciences(CIFMS)grant nos.2021-I2M-1-021 and 2022-I2M-JB-008 to B.H.; Solid tumor cells live in a highly dynamic mechanical microenvironment.How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma.Here,we show tha...; 关键词：ACTIVATION thereby MAF

Pancreatic β-cell failure,clinical implications,and therapeutic strategies in type 2 diabetes被引量：2: 《Chinese Medical Journal》2024年第7期791-805,共15页Daxin Cui Xingrong Feng Siman Lei Hongmei Zhang Wanxin Hu Shanshan Yang Xiaoqian Yu Zhiguang Su; National Natural Science Foundation of China(Nos.82270846 and 81770814);Sichuan Science and Technology Program(No.2023JDRC0095);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(No.Z20201010); Pancreaticβ-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes(T2D).Reserving insulin-producingβ-cells and hence restoring insulin pr...; 关键词：Pancreaticβ-cell regeneration Diabetes INSULIN DEDIFFERENTIATION TRANSDIFFERENTIATION Stem cell

Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling被引量：3: 《Acta Pharmacologica Sinica》2024年第1期98-111,共14页Shuang Yang Hou-wei Li Jia-ying Tian Zheng-kai Wang Yi Chen Ting-ting Zhan Chun-yue Ma Min Feng Shifeng Cao Yu Zhao Xue Li Jing Ren Qian Liu Lu-ying Jin Zhi-qi Wang Wen-yu Jiang Yi-xiu Zhao Yan Zhang Xue Liu; supported by National Natural Science Foundation of China(82170431,81870259,81903608).; Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell(VSMC)dedifferentiation.Myeloid-derived growth factor(MYDGF),secreted from bone marrow-derived...; 关键词：carotid artery balloon injury neointimal formation VSMC dedifferentiation MYDGF Sphingosine-1-phosphate receptor 2

The Warburg effect drives dedifferentiation through epigenetic reprogramming: 《Cancer Biology & Medicine》2023年第12期891-897,共7页Haowen Jiang Mohamed Jedoui Jiangbin Ye; supported by a Stanford Maternal and Child Health Research Institute Research Scholar Award (2020);an American Cancer Society Research Scholar Grant (RSG-20-036-01);an Agilent Solutions Innovation Research Award (SIRA) to J.Y.; German biochemist and cell physiologist,Otto H.Warburg(Figure 1),made a groundbreaking discovery in 1923.Specifically,tumors were shown to consume large amounts of glucose and ferment glucose into lactate,even in the ...; 关键词：WARBURG EFFECT FIGURE

Mechanism of hepatocytes differentiation and dedifferentiation in liver regeneration:Process and exploration: 《Hepatobiliary & Pancreatic Diseases International》2023年第4期331-332,共2页Zhangyuting He Hua-Yu Yang; The liver has roles in many processes,including metabolism,synthesis,and biotransformation.It is unique among all visceral organs,as it even can regenerate after injury.A common research model of liver regeneration is...; 关键词：MEDIAL METABOLISM ORGANS

Organoid-derived human retinal progenitor cells promote early dedifferentiation of Müller glia in Royal College of Surgeons rats: 《International Journal of Ophthalmology(English edition)》2023年第4期483-498,共16页Qiang Guo Yu-Xiao Zeng Shu-Dong Huang Ting Zou Zheng-Qin Yin; Supported by the National Key Research and Development Program of China(No.2018YFA0107302);the Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-msxm X0437)。; AIM:To explore whether the subretinal transplantation of retinal progenitor cells from human embryonic stem cell-derived retinal organoid(h ERO-RPCs)could promote Müller glia dedifferentiation and transdifferentiatio...; 关键词：retinal degeneration retinal organoid retinal progenitor cells subretinal transplantation Muller glia DEDIFFERENTIATION

A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration被引量：6: 《Bone Research》2022年第3期578-593,共16页Yishan Chen Yeke Yu Ya Wen Juan Chen Junxin Lin Zixuan Sheng Wenyan Zhou Heng Sun Chengrui An Jiansong Chen Weiliang Wu Chong Teng Wei Wei Hongwei Ouyang; supported by the National Key R&D Program of China(2017YFA0104900);National Natural Science Foundation of China(T2121004,31830029,82002319)。; Articular cartilage damage is a universal health problem.Despite recent progress,chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.Loss-of-function chang...; 关键词：CHONDROCYTE CARTILAGE metabolism

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