Oral pathogen aggravates atherosclerosis by inducing smooth muscle cell apoptosis and repressing macrophage efferocytosis  

作　　者：Hanyu Xie Ziyue Qin Ziji Ling Xiao Ge Hang Zhang Shuyu Guo Laikui Liu Kai Zheng Hongbing Jiang Rongyao Xu 

机构地区：[1]Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China [2]Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,China [3]Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing Medical University,Nanjing,China [4]Department of Periodontology,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China [5]Department of Orthodontics,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China

出　　处：《International Journal of Oral Science》2023年第2期332-346,共15页国际口腔科学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(grants82001012,81970910,and 81771092);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(grants 19KJA360003);China Postdoctoral Science Foundation(2021M691640)。

摘　　要：Periodontitis imparting the increased risk of atherosclerotic cardiovascular diseases is partially due to the immune subversion of the oral pathogen,particularly the Porphyromonas gingivalis(P.gingivalis),by inducing apoptosis.However,it remains obscure whether accumulated apoptotic cells in P.gingivalis-accelerated plaque formation are associated with impaired macrophage clearance.

关 键 词：IMPAIRED MACROPHAGE cardiovascular 

分 类 号：R781.42[医药卫生—口腔医学] R543.5[医药卫生—临床医学]