NEUROVIRULENCE

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SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids
《Research》2025年第1期107-120,共14页Weikang Chen Xiaobing Jiang Wei Liang Haojie Bai Mingze Xu Zhe Liu Lina Yi Yanming Liu Yanxia Huang Yongxin Zhang Lixia Xu Baoshu Xie Nu Zhang Jun Yu Jing Lu Haipeng Xiao Xiaoxing Li 
supported by Guangdong Science and Technology Program(2021B1212030007)from Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response,National Natural Science Foundation of China(82372624);National Natural Science Foundation of Guangdong Province(2022A1515012430);China Postdoctoral Science Foundation(2022M723588);Medical Scientific Research Foundation of Guangdong Province(A2023439);GuangDong Basic and Applied Basic Research Foundation(2023A1515110422).
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals.However,whether and how aging brains are affected by Omicron variants in t...
关键词：brain tissue aging brains Omicron variants primary brain spheroids bss Elderly brain spheroids NEUROVIRULENCE 
A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo
《Virologica Sinica》2022年第1期115-126,共12页Zhihua Liu Yawei Zhang Mengli Cheng Ningning Ge Jiayi Shu Zhiheng Xu Xiao Su Zhihua Kou Yigang Tong Chengfeng Qin Xia Jin 
supported in part by the following grants:Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29040301 to X.J.);National Key R&D Program of China(2016YFC1201000 to X.J.);Ministry of Science and Technology of China(2016YFE0133500 to X.J.);the National Natural Science Foundation of China(31770190 and 81925025 to CF.Q.);European Union Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement(734548 to X.J.)
Zika virus(ZIKV)can infect a wide range of tissues including the developmental brain of human fetus.Whether specific viral genetic variants are linked to neuropathology is incompletely understood.To address this,we ha...
关键词：Zika virus(ZIKV) Envelope protein D67N MUTATION NEUROVIRULENCE 
Did ZIKV evolve to be more dangerous? A new clue towards neurovirulence
《National Science Review》2018年第2期121-122,共2页Gary Wong George F.Gao 
Before 2015,Zika virus(ZIKV)was a little-known flavivirus that caused sporadic symptomatic infections in humans(under 20 reported cases,but likely manymore unreported asymptomatic cases)in the decades following its di...
关键词：DANGEROUS likely SPORADIC evolve illness Africa ASYMPTOMATIC mutation PATHOGENIC VITAL 
Comparative Genomic Analysis of Enterovirus 71 Revealed Six New Potential Neurovirulence-associated Sites被引量：6
《Biomedical and Environmental Sciences》2016年第10期767-772,共6页JIA Qing Jun CHEN Xin Yu LI De Zhou XU Juan Juan XU Zhi Gang DUAN Zhi Liang WEN Jin Sheng 
funded by Natural Science Foundation of Zhejiang(LQ14C010006);National Natural Science Foundation of China(81501363);Planned Science and Technology Project of Zhejiang(2014C33261)
In the present study,the complete genomes of four common（4/EV71/Wenzhou/CHN/2014,15/EV71/Wenzhou/CHN/2014,116/EV71/Wenzhou/CHN/2014,and 120/EV71/Wenzhou/CHN/2014）and two virulent（11/EV71/Wenzhou/CHN/2014and 109/EV7...
关键词：CHN UTR EV Comparative Genomic Analysis of Enterovirus 71 Revealed Six New Potential Neurovirulence-associated Sites 
Role of the virion host shutoff protein in neurovirulence of monkey B virus(Macacine herpesvirus 1)被引量：1
《Virologica Sinica》2014年第5期274-283,共10页Darla Black Jerry Ritchey Mark Payton Richard Eberle 
supported in part by PHS grants 2P40 OD010988 and 1P40 OD010431
Monkey B virus(Macacine herpesvirus 1; BV) is noted for its extreme neurovirulence in humans. Since the vhs protein encoded by the UL41 gene has been shown to be a neurovirulence factor in the related human herpes sim...
关键词：HERPESVIRUS MONKEY B virus UL41 VIRION HOST shutoff NEUROVIRULENCE 
Varicella zoster virus vaccines: potential complications and possible improvements被引量：5
《Virologica Sinica》2014年第5期265-273,共9页Benjamin Silver Hua Zhu 
Varicella zoster virus(VZV) is the causative agent of varicella(chicken pox) and herpes zoster(shingles). After primary infection, the virus remains latent in sensory ganglia, and reactivates upon weakening of the cel...
关键词：VARICELLA ZOSTER virus HERPESVIRUS vaccine NEUROVIRULENCE neuro-attenuation latency latent infection herpes ZOSTER SHINGLES chicken pox ORF7 
Study on the determinants of suckling mice neurovirulence of dengue 2 virus
《Science China(Life Sciences)》2003年第1期95-103,共9页赵卫 范宝昌 胡志君 陈水平 王鹏程 苑锡同 李晓萸 于曼 秦鄂德 杨佩英 
The National Natural Science Foundation of China (Grant No. 30000144).
pDVWS501 was a genomic-length cDNA clone of dengue 2 virus, through which infec-tious virus (MON501) could be rescued. MON501 was neurovirulent in mice, whose E residues 62 and 203 were Lys and Asn, respectively. Two ...
关键词：DENGUE 2 virus  VIRULENT determinants  infectious transcripts  point mutation. 
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