VIRION

作品数：27被引量：38H指数：4
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相关领域：医药卫生更多>>
相关作者：李晶高虹于丹吴俊燏郭万申更多>>
相关机构：北京科兴生物制品有限公司河南省疾病预防控制中心哈尔滨医科大学附属第二医院哈尔滨医科大学更多>>
相关期刊：《Chinese Medical Journal》《Science Bulletin》《中华流行病学杂志》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains
《Asian Pacific Journal of Tropical Medicine》2023年第2期92-94,I0008,共4页Shilpa Barthwal Bennet Angel Annette Angel Vinod Joshi BM Shareef Nuzhat M Peer Poorna Khaneja Ambreen S Khan Bhawna Sharma Neha Singh Ramesh Joshi Komal Tomar Kiran Yadav Satendra P Singh 
funded by Indian Council of Medical Research,Grant Number 2021-6369.
Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern viz.Delta and Omicron strain.As we are using vaccines which are either mRNA of spike protein of ...
关键词：VACCINE ANTIBODIES neutral 
Characterization of Episomal Replication of Bovine Papillomavirus Type 1 DNA in Long-Term Virion-Infected Saccharomyces Cerevisiae Culture
《Virologica Sinica》2021年第6期1492-1502,共11页Quanmei Tu Weixu Feng Zhuo Chen Qijia Li Yu Zhao Jun Chen Pengfei Jiang Xiangyang Xue Lifang Zhang Kong-Nan Zhao 
This work was funded in part by grants from the National Nature Science Foundation of China(81772791 and 81172463)。
We have previously reported that bovine papillomavirus type 1(BPV-1) DNA can replicate its genome and produce infectious virus-like particles in short term virion-infected S. cerevisiae(budding yeast) cultures(Zhao an...
关键词：Bovine papillomavirus type 1(BPV-1) Saccharomyces cerevisiae Genomic DNA replication Agarose gel electrophoresis Southern blot hybridization 
Open reading frame 3 protein of hepatitis E virus:Multi-function protein with endless potential被引量：4
《World Journal of Gastroenterology》2021年第20期2458-2473,共16页Yong-Lin Yang Yu-Chen Nan 
National Natural Science Foundation of China,No.31672534;Key Project supported by Medical Science and Technology Development Foundation of Nanjing Department of Health,No.ZKX19026.
Hepatitis E virus (HEV), a fecal-orally transmitted foodborne viral pathogen,causes acute hepatitis in humans and is responsible for hepatitis E outbreaksworldwide. Since the identification of HEV as a zoonotic agent,...
关键词：Hepatitis E virus ZOONOSIS Quasi-enveloped virion Hepatitis E virus-open reading frame 3 Innate immunity 
Proteomic Profiling of Purified Rabies Virus Particles
《Virologica Sinica》2020年第2期143-155,共13页Yan Zhang Yuyang Wang Ye Feng Zhongzhong Tu Zhiyong Lou Changchun Tu 
This research was funded by the National Key Research and Development Plan(Grant No.2016YFD0500401);National Natural Science Foundation of China(Grant No.31402214);China Postdoctoral Science Foundation(Grant No.2014M552638).
While host proteins incorporated into virions during viral budding from infected cell are known to play essential roles in multiple process of the life cycle of progeny virus,these characteristics have been largely ne...
关键词：Rabies virus(RABV) PURIFICATION Virion structure Virion proteome 
Cryo-EM Studies of Virus-Antibody Immune Complexes
《Virologica Sinica》2020年第1期1-13,共13页Na Li Zhiqiang Li Yan Fu Sheng Cao 
the National Natural Science Foundation of China(Grant Nos.31570161 and 31770169);the“One-Three-Five”Strategic Programs of the Wuhan Institute of Virology,Chinese Academy of Sciences(Grant No.Y605211SA3).
Antibodies play critical roles in neutralizing viral infections and are increasingly used as therapeutic drugs and diagnostic tools. Structural studies on virus-antibody immune complexes are important for better under...
关键词：Cryo-electron microscopy(Cryo-EM) ICOSAHEDRAL ANTIGEN VIRION IMMUNE complex 
Geometric architecture of viruses
《World Journal of Virology》2020年第2期5-18,共14页Mohammad Khalid Parvez 
In the current SARS-CoV-2 disease(COVID-19)pandemic,the structural understanding of new emerging viruses in relation to developing effective treatment and interventions are very necessary.Viruses present remarkable di...
关键词：VIRUS VIRION Capsid structure ICOSAHEDRON Triangulation number 
Complementation of Wild-Type and Drug-Resistant Hepatitis B Virus Genomes to Maintain Viral Replication and Rescue Virion Production under Nucleos(t)ide Analogs被引量：5
《Virologica Sinica》2019年第4期377-385,共9页Chunchen Wu Baolin Li Xiaoyong Zhang Kaitao Zhao Yingshan Chen Yifei Yuan Yan Liu Rongjuan Chen Dongping Xu Xinwen Chen Mengji Lu 
supported by the Deutsche Forschungsgemeinschaft (TRR60);the National Nature Science Foundation of China (31770180, 31621061);the Youth Innovation Promotion Association CAS (No. 2016303);the Youth Planning Project of Hubei Health Planning Commission (WJ2017Q027)
As the open reading frames of hepatitis B virus(HBV)genomes are overlapping,resistance mutations(MTs)in HBV polymerase may result in stop codon MTs in hepatitis B surface proteins,which are usually detected as a mixed...
关键词：Hepatitis B virus(HBV) Viral replication Nucleos(t)ide ANALOGS resistance mutations Surface truncation mutation 
Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release
《World Journal of Gastroenterology》2018年第12期1299-1311,共13页Qi Wang Yue Li Shun-Ai Liu Wen Xie Jun Cheng 
Beijing Natural Science Foundation,No.7161006;Beijing Municipal Administration of Hospitals’ Youth Program,No.QML20161801 and No.QML20171801
AIM To explore hepatitis C virus(HCV) adaptive mutations or combinations thereof responsible for enhanced viral production and investigate the underlying mechanisms.METHODS A series of plasmids with adaptive mutations...
关键词：HEPATITIS C virus JFH1 Adaptive mutation RNA REPLICATION VIRION RELEASE Lipid droplet localization 
Possibility of Evolution in Culture of the <i>Oryctes</i>Nudivirus of the Coconut Rhinoceros Beetle <i>Oryctes rhinoceros</i>(Coleoptera: Scarabaeidae: Dynastinae)
《Advances in Entomology》2018年第1期27-33,共7页Geoffrey O. Bedford 
It is suggested that the isolates of Oryctes Nudivirus (OrNV), cultured for decades in cells of Heteronychus arator (F.) (HA), be checked to verify genomic changes have not occurred which adapt them to culture but red...
关键词：Oryctes RHINOCEROS Haplotype Oryctes Nudivirus OrNV Heteronychus arator HA VIRION 
Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population被引量：5
《World Journal of Gastroenterology》2018年第6期680-692,共13页Rosario Casillas David Tabernero Josep Gregori Irene Belmonte Maria Francesca Cortese Carolina González Mar Riveiro-Barciela Rosa Maria López Josep Quer Rafael Esteban Maria Buti Francisco Rodríguez-Frías 
Supported by Instituto de Salud Carlos Ⅲ,No.PI14/01416 and No.PI15/00856;cofinanced by the European Regional Development Fund(ERDF);the Gilead Fellowship Program,No.GLD14-00296
AIM To determine the variability/conservation of the domain of hepatitis B virus(HBV) pre S1 region that interacts with sodium-taurocholate cotransporting polypeptide(hereafter, NTCP-interacting domain) and the preval...
关键词：HEPATITIS B VIRUS HEPATITIS B VIRUS PRES1 region sodium-taurocholate co-transporting polypeptide NTCP-interacting DOMAIN VIRION morphogenesis DOMAIN SNP rs2296651 next-generation sequencing real-time PCR melting curves 
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