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Pyrrole and pyrrolidine analogs:The promising scaffold in discovery of pesticides
《Chinese Chemical Letters》2025年第3期113-124,共12页Anjing Liao Wei Sun Yaming Liu Han Yan Zhi Xia Jian Wu 
financial support from the National Natural Science Foundation of China(No.32072445);the Science and Technology Plan Project of Guizhou Province(Qiankehezhicheng[2024]the general 083);the Program of Introducing Talents to Chinese Universities(No.D20023);the Central Government Guides Local Science and Technology Development Fund Projects(Qiankehezhongyindi(2023)001);Key Agricultural Technology R&D Projects of the Xinjiang Production and Construction Corps(NYHXGG,2023AA602);the Frontiers Science Centre for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004];the specific research fund of The Innovation Platform for Academicians of Hainan Province(No.SQ2020PTZ0009);。
Pyrrole is a heterocycle with four carbon atoms and a nitrogen atom,which is extensively used in the pesticide and pharmaceutical industries.In addition,it has a series of analogs such as pyrrolidine,pyrroline,and pyr...
关键词：PYRROLE PYRROLIDONE Agrochemicals Biological activity Structure-activity relationship 
Balancing functions of antifouling,nitric oxide release and vascular cell selectivity for enhanced endothelialization of assembled multilayers
《Regenerative Biomaterials》2025年第1期126-141,共16页Sulei Zhang Jun Sun Shuaihang Guo Yichen Wang Yuheng Zhang Jiao Lei Xiaoli Liu Hong Chen 
supported primarily by the National Natural Science Foundation of China(22075191,21774089,and 21935008);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function,Soochow University;the Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application,Soochow University.
Surface endothelialization is a promising way to improve the hemocompatibility of biomaterials.However,current surface endothelialization strategies have limitations.For example,various surface functions are not well ...
关键词：surface modification layer-by-layer self-assembly nitric oxide release heparin analogs ENDOTHELIALIZATION 
The mechanistic role of curcumin and its analogs in NSCLC:An evaluation of cell death in preclinical studies
《Malignancy Spectrum》2024年第4期263-274,共12页Ela Kesen Boztas Sevki Mustafa Demiroz Hacer Ilke Onen 
Lung cancer is the leading malignancy among males and ranks the second in females,with an estimated two million new diagnoses annually.It ranks the first in cancer-related deaths among men and the second,following bre...
关键词：cell death pathway CURCUMIN curcumin analog non-small cell lung cancer 
Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside(acid)analogs for hepatitis B virus
《World Journal of Hepatology》2024年第12期1395-1406,共12页Hua-Dong Li Ya-Nan Liu Shuang Wu Xu-Feng Quan Xiao-Yan Wang Tian-Dan Xiang Shu-Meng Li Ling Xu Tong Wang Hua Wang Xin Zheng 
Supported by National Science and Technology Major Project of China,No.92169121;National Key R and D Projects,No.2022YFC2305100;Wuhan Science and Technology Bureau Knowledge Innovation Special Foundation of Hubei Province,No.2022020801010588.
BACKGROUND The effect of nonalcoholic fatty liver disease(NAFLD)on the efficacy of nucleoside analogues(NAs)in antiviral therapy for patients with chronic hepatitis B(CHB)remains controversial.AIM To investigate the i...
关键词：Nonalcoholic fatty liver disease Chronic hepatitis B Nucleoside analogues Antiviral therapy Virological response 
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
《Current Medical Science》2024年第5期890-901,共12页Bi-qiong ZHANG Feng-qing WANG Jie YIN Xiao-tan YU Zheng-xi HU Liang-hu GU Qing-yi TONG Yong-hui ZHANG 
financially supported by the National Natural Science Foundation of China(No.81903461);the Natural Science Foundation of Hubei Province(No.ZRMS2023000340).
Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult...
关键词：pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction APOPTOSIS 
Long-term hepatitis B surface antigen kinetics after nucleos(t)ide analog discontinuation in patients with noncirrhotic chronic hepatitis B
《Liver Research》2024年第3期179-187,共9页Lina Wu Jiadi Lai Qiumin Luo Yeqiong Zhang Chaoshuang Lin Dongying Xie Youming Chen Hong Deng Zhiliang Gao Liang Peng Wenxiong Xu 
Natural Science Foundation of China(No.82070611 to Liang Peng);Natural Science Foundation of Guangdong Province(No.2020A1515010317 to Liang Peng);GuangDong Basic and Applied Basic Research Foundation(No.21202104030000608 and 2021A1515220029 to Liang Peng);Guangzhou Science and Technology Plan Projects(No.202102010204 and 2023B03J1287 to Liang Peng,No.202102080064 to Wenxiong Xu);Sun Yat-Sen University Clinical Research 5010 Program(No.2020007 and 2018009 to Liang Peng);Transformation of Scientific and Technological Achievements Project of Sun Yat-sen University(No.82000-18843236 to Liang Peng);Five-Year Plan of Third Affiliated Hospital of Sun Yat-sen University(No.K00006 and P02421 to Liang Peng).
Background and aim Few studies have reported hepatitis B surface antigen(HBsAg)kinetics after nucleos(t)ide analog(NA)discontinuation in patients with noncirrhotic chronic hepatitis B(CHB).The study specifically inves...
关键词：Hepatitis B virus(HBV) Chronic hepatitis B(CHB) Hepatitis B surface antigen(HBsAg) Nucleos(t)ide analogs(NAs) Quantitative HBsAg KINETICS 
Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A
《有机化学》2024年第7期2350-2362,共13页Yang Shuai Wu Jie Wang Liangliang 
Project supported by the High-Level Talent Program of Yunnan Province(No.Y93D321261);the Regional Development Program for Young Scholars,Chinese Academy of Sciences(CAS)(No.E323521311);the Science and Technology Department of Yunan Province(Nos.202305AH34005,202401AS070096)。
Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in tota...
关键词：asymmetric total synthesis coupling reaction simplified analog elansolid A 
Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan:Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs
《CCS Chemistry》2024年第6期1448-1457,共10页Yuan Xu Shihao Song Hongwei Duan Yinyue Deng Xue-Wei Liu 
the Ministry of Education(grant nos.MOET2EP30120-0007 and MOE2018-T2-2-128);the National Research Foundation(grant no.NRF-CRP22-2019-0002);Agency for Science,Technology and Research(A*STAR);Singapore(grant no.A20E5c0087);the National Natural Science Foundation of China(grant no.32300033);the Scientific Research Foundation of Hainan University(grant nos.KYQD(ZR)-22173 and KYQD(ZR)-23006).
The emergence of microbial drug resistance,coupled with the paucity of new antibiotics poses an impending threat to public health.In this work,we drew inspiration from synthetic peptidoglycan oligomers and successfull...
关键词：CHITOSAN bacterial infection endogenous antibodies bacterial surface engineering peptidoglycan analogs 
Helicene-type β-isoindigo-based boron-dipyrromethene analogs with strong near-infrared chiroptical activity
《Aggregate》2024年第3期268-274,共7页Ziwei Chen Zhigang Ni Xing-Yu Chen Yongqiang Xu Chunyan Yu SiSi Wang Xiao-Ye Wang Hua Lu 
National Natural Science Foundation of China,Grant/Award Numbers:21871072,22003014;Hangzhou Normal University。
Near-infrared(NIR)chiroptical response has been less explored because it is chal-lenging to achieve both chirality and NIR absorption/emission.Herein,we describe the design of heterohelicene-typeβ-isoindigo-based bor...
关键词：BODIPY chiroptical activity circularly polarized luminescence HELICENE NEAR-INFRARED 
Acarbose glycosylation by AcbE for the production of acarstatins with enhancedα-amylase inhibitory activity
《Synthetic and Systems Biotechnology》2024年第2期359-368,共10页Xin Zhang Qungang Huang Ziyue Guo Feifei Cai Qianjin Kang Linquan Bai 
This work was supported by the National Key Research and Development Program of China(grant No.2021YFC2100600);National Natural Science Foundation of China(grant No.31830104);Science and Technology Commission of Shanghai Municipality(grant Nos.19JC1413000 and 19430750600)to L.B.We thank the Core Facility and Technical Service Center for SLSB and the Instrumental Analysis Center in SJTU for data collection.
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus(T2DM).Various acarbose analogs have been identified while exploring compounds with improved pharmacological ...
关键词：Acarbose analogs α-amylase inhibitory activity Actinoplanes sp. Transglycosylase 
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